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Akt-dependent regulation of NF-κB is controlled by mTOR and Raptor in association with IKK

While NF-κB is considered to play key roles in the development and progression of many cancers, the mechanisms whereby this transcription factor is activated in cancer are poorly understood. A key oncoprotein in a variety of cancers is the serine–threonine kinase Akt, which can be activated by mutat...

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Autori principali: Dan, Han C., Cooper, Matthew J., Cogswell, Patricia C., Duncan, Joseph A., Ting, Jenny P.-Y., Baldwin, Albert S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2418585/
https://ncbi.nlm.nih.gov/pubmed/18519641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1662308
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