The ubiquitin system: from cell signalling to disease biology and new therapeutic opportunities

Autor Damgaard, Rune Busk
Vydáno v Cell Death Differ (2021)

Met1-linked ubiquitin signalling in health and disease: inflammation, immunity, cancer, and beyond

Autor Jahan, Akhee Sabiha, Elbæk, Camilla Reiter, Damgaard, Rune Busk
Vydáno v Cell Death Differ (2021)

OTULIN deficiency in ORAS causes cell type‐specific LUBAC degradation, dysregulated TNF signalling and cell death

Autor Damgaard, Rune Busk, Elliott, Paul R, Swatek, Kirby N, Maher, Eamonn R, Stepensky, Polina, Elpeleg, Orly, Komander, David, Berkun, Yackov
Vydáno v EMBO Mol Med (2019)

OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer

Autor Damgaard, Rune Busk, Jolin, Helen E., Allison, Michael E. D., Davies, Susan E., Titheradge, Hannah L., McKenzie, Andrew N. J., Komander, David
Vydáno v Cell Death Differ (2020)

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling

Autor Fiil, Berthe Katrine, Damgaard, Rune Busk, Wagner, Sebastian Alexander, Keusekotten, Kirstin, Fritsch, Melanie, Bekker-Jensen, Simon, Mailand, Niels, Choudhary, Chunaram, Komander, David, Gyrd-Hansen, Mads
Vydáno 2013

Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling

Autor Damgaard, Rune Busk, Fiil, Berthe Katrine, Speckmann, Carsten, Yabal, Monica, zur Stadt, Udo, Bekker-Jensen, Simon, Jost, Philipp J, Ehl, Stephan, Mailand, Niels, Gyrd-Hansen, Mads
Vydáno 2013

CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

Autor Hrdinka, Matous, Fiil, Berthe Katrine, Zucca, Mattia, Leske, Derek, Bagola, Katrin, Yabal, Monica, Elliott, Paul R., Damgaard, Rune Busk, Komander, David, Jost, Philipp J., Gyrd-Hansen, Mads
Vydáno v Cell Rep (2016)

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin

Autor Keusekotten, Kirstin, Elliott, Paul Ronald, Glockner, Laura, Fiil, Berthe Katrine, Damgaard, Rune Busk, Kulathu, Yogesh, Wauer, Tobias, Hospenthal, Manuela Kathrin, Gyrd-Hansen, Mads, Krappmann, Daniel, Hofmann, Kay, Komander, David
Vydáno 2013

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

Autor Damgaard, Rune Busk, Walker, Jennifer A., Marco-Casanova, Paola, Morgan, Neil V., Titheradge, Hannah L., Elliott, Paul R., McHale, Duncan, Maher, Eamonn R., McKenzie, Andrew N.J., Komander, David
Vydáno v Cell (2016)