The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

Methionine-1 (M1)-linked ubiquitin chains regulate the activity of NF-κB, immune homeostasis, and responses to infection. The importance of negative regulators of M1-linked chains in vivo remains poorly understood. Here, we show that the M1-specific deubiquitinase OTULIN is essential for preventing...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell
Prif Awduron: Damgaard, Rune Busk, Walker, Jennifer A., Marco-Casanova, Paola, Morgan, Neil V., Titheradge, Hannah L., Elliott, Paul R., McHale, Duncan, Maher, Eamonn R., McKenzie, Andrew N.J., Komander, David
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cell Press 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5002269/
https://ncbi.nlm.nih.gov/pubmed/27523608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.07.019
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