An Insulin-Sensitizing Thiazolidinedione, Which Minimally Activates PPARγ, Does Not Cause Bone Loss

Autor Fukunaga, Tomohiro, Zou, Wei, Rohatgi, Nidhi, Colca, Jerry R., Teitelbaum, Steven L.
Vydáno v J Bone Miner Res (2015)

Treating fatty liver disease by modulating mitochondrial pyruvate metabolism

Autor Colca, Jerry R., McDonald, William G., McCommis, Kyle S., Finck, Brian N.
Vydáno v Hepatol Commun (2017)

Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide

Autor Kamm, Dakota R., Pyles, Kelly D., Sharpe, Martin C., Healy, Laura N., Colca, Jerry R., McCommis, Kyle S.
Vydáno v J Biol Chem (2021)

Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains β-Cell Phenotype in Human Islets

Autor Rohatgi, Nidhi, Aly, Haytham, Marshall, Connie A., McDonald, William G., Kletzien, Rolf F., Colca, Jerry R., McDaniel, Michael L.
Vydáno 2013

An Evaluation of MSDC-0160, A Prototype mTOT Modulating Insulin Sensitizer, in Patients with Mild Alzheimer’s Disease

Autor Shah, Raj C, Matthews, Dawn C, Andrews, Randolph D, Capuano, Ana W, Fleischman, Debra A, VanderLugt, James T, Colca, Jerry R
Vydáno 2014

Loss of Mitochondrial Pyruvate Carrier 2 in Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling

Autor McCommis, Kyle S., Chen, Zhouji, Fu, Xiaorong, McDonald, William G., Colca, Jerry R., Kletzien, Rolf F., Burgess, Shawn C., Finck, Brian N.
Vydáno v Cell Metab (2015)

Insulin Resistance and Metabolic Derangements in Obese Mice Are Ameliorated by a Novel Peroxisome Proliferator-activated Receptor γ-sparing Thiazolidinedione

Autor Chen, Zhouji, Vigueira, Patrick A., Chambers, Kari T., Hall, Angela M., Mitra, Mayurranjan S., Qi, Nathan, McDonald, William G., Colca, Jerry R., Kletzien, Rolf F., Finck, Brian N.
Vydáno 2012

Targeting the Mitochondrial Pyruvate Carrier Attenuates Fibrosis in a Mouse Model of Nonalcoholic Steatohepatitis

Autor McCommis, Kyle S., Hodges, Wesley T., Brunt, Elizabeth M., Nalbantoglu, ILKe, McDonald, William G., Holley, Christopher, Fujiwara, Hideji, Schaffer, Jean E., Colca, Jerry R., Finck, Brian N.
Vydáno v Hepatology (2017)

The Beneficial Metabolic Effects of Insulin Sensitizers are not Attenuated by Mitochondrial Pyruvate Carrier 2 Hypomorphism

Autor Vigueira, Patrick A., McCommis, Kyle S., Hodges, Wesley T., Schweitzer, George G., Cole, Serena L., Oonthonpan, Lalita, Taylor, Eric B., McDonald, William G., Kletzien, Rolf F., Colca, Jerry R., Finck, Brian N.
Vydáno v Exp Physiol (2017)

Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion

Autor Vigueira, Patrick A., McCommis, Kyle S., Schweitzer, George G., Remedi, Maria S., Chambers, Kari T., Fu, Xiaorong, McDonald, William G., Cole, Serena L., Colca, Jerry R., Kletzien, Rolf F., Burgess, Shawn C., Finck, Brian N.
Vydáno 2014

Insulin Sensitizing Pharmacology of Thiazolidinediones Correlates with Mitochondrial Gene Expression rather than Activation of PPARγ

Autor Bolten, Charles W., Blanner, Patrick M., McDonald, William G., Staten, Nicholas R., Mazzarella, Richard A., Arhancet, Graciela B., Meier, Martin F., Weiss, David J., Sullivan, Patrick M., Hromockyj, Alexander E., Kletzien, Rolf F., Colca, Jerry R.
Vydáno 2007

Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier

Autor Divakaruni, Ajit S., Wiley, Sandra E., Rogers, George W., Andreyev, Alexander Y., Petrosyan, Susanna, Loviscach, Mattias, Wall, Estelle A., Yadava, Nagendra, Heuck, Alejandro P., Ferrick, David A., Henry, Robert R., McDonald, William G., Colca, Jerry R., Simon, Melvin I., Ciaraldi, Theodore P., Murphy, Anne N.
Vydáno 2013

Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)—Relationship to Newly Identified Mitochondrial Pyruvate Carrier Proteins

Autor Colca, Jerry R., McDonald, William G., Cavey, Gregory S., Cole, Serena L., Holewa, Danielle D., Brightwell-Conrad, Angela S., Wolfe, Cindy L., Wheeler, Jean S., Coulter, Kristin R., Kilkuskie, Peter M., Gracheva, Elena, Korshunova, Yulia, Trusgnich, Michelle, Karr, Robert, Wiley, Sandra E., Divakaruni, Ajit S., Murphy, Anne N., Vigueira, Patrick A., Finck, Brian N., Kletzien, Rolf F.
Vydáno 2013