Identification and molecular basis for SIRT6 loss-of-function point mutations in cancer

par Kugel, Sita, Feldman, Jessica L., Klein, Mark A., Silberman, Dafne M., Sebastián, Carlos, Mermel, Craig, Dobersch, Stephanie, Clark, Abbe R., Getz, Gad, Denu, John M., Mostoslavsky, Raul
Publié dans Cell Rep (2015)

Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities

par Christov, Marta, Clark, Abbe R., Corbin, Braden, Hakroush, Samy, Rhee, Eugene P., Saito, Hiroaki, Brooks, Dan, Hesse, Eric, Bouxsein, Mary, Galjart, Niels, Jung, Ji Yong, Mundel, Peter, Jüppner, Harald, Weins, Astrid, Greka, Anna
Publié dans JCI Insight (2018)

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models

par Zhou, Yiming, Castonguay, Philip, Sidhom, Eriene-Heidi, Clark, Abbe R., Dvela-Levitt, Moran, Kim, Sookyung, Sieber, Jonas, Wieder, Nicolas, Jung, Ji Yong, Andreeva, Svetlana, Reichardt, Jana, Dubois, Frank, Hoffmann, Sigrid C., Basgen, John M., MontesinoS, Mónica S., Weins, Astrid, Johnson, Ashley C., Lander, Eric S., Garrett, Michael R., Hopkins, Corey R., Greka, Anna
Publié dans Science (2017)

A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury

par Kost-Alimova, Maria, Sidhom, Eriene-Heidi, Satyam, Abhigyan, Chamberlain, Brian T., Dvela-Levitt, Moran, Melanson, Michelle, Alper, Seth L., Santos, Jean, Gutierrez, Juan, Subramanian, Ayshwarya, Byrne, Patrick J., Grinkevich, Elizabeth, Reyes-Bricio, Estefanía, Kim, Choah, Clark, Abbe R., Watts, Andrew J.B., Thompson, Rebecca, Marshall, Jamie, Pablo, Juan Lorenzo, Coraor, Juliana, Roignot, Julie, Vernon, Katherine A., Keller, Keith, Campbell, Alissa, Emani, Maheswarareddy, Racette, Matthew, Bazua-Valenti, Silvana, Padovano, Valeria, Weins, Astrid, McAdoo, Stephen P., Tam, Frederick W.K., Ronco, Luciene, Wagner, Florence, Tsokos, George C., Shaw, Jillian L., Greka, Anna
Publié dans Cell Rep Med (2020)