TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State

by Cardaci, Simone, Ciriolo, Maria Rosa
Published 2012

Deprive to kill: Glutamine closes the gate to anticancer monocarboxylic drugs

by Cardaci, Simone, Ciriolo, Maria Rosa
Published 2012

MAPK14/p38α-dependent modulation of glucose metabolism affects ROS levels and autophagy during starvation

by Desideri, Enrico, Vegliante, Rolando, Cardaci, Simone, Nepravishta, Ridvan, Paci, Maurizio, Ciriolo, Maria Rosa
Published 2014

The isatin-Schiff base copper(II) complex Cu(isaepy)(2) acts as delocalized lipophilic cation, yields widespread mitochondrial oxidative damage and induces AMP-activated protein ki...

by Filomeni, Giuseppe, Piccirillo, Sara, Graziani, Ilaria, Cardaci, Simone, Da Costa Ferreira, Ana M., Rotilio, Giuseppe, Ciriolo, Maria R.
Published 2009

S-Nitrosoglutathione Reductase Plays Opposite Roles in SH-SY5Y Models of Parkinson's Disease and Amyotrophic Lateral Sclerosis

by Rizza, Salvatore, Cirotti, Claudia, Montagna, Costanza, Cardaci, Simone, Consales, Claudia, Cozzolino, Mauro, Carrì, Maria Teresa, Cecconi, Francesco, Filomeni, Giuseppe
Published in Mediators Inflamm (2015)

D-mannose suppresses macrophage IL-1β production

by Torretta, Simone, Scagliola, Alessandra, Ricci, Luisa, Mainini, Francesco, Di Marco, Sabrina, Cuccovillo, Ivan, Kajaste-Rudnitski, Anna, Sumpton, David, Ryan, Kevin M., Cardaci, Simone
Published in Nat Commun (2020)

S-nitrosylation drives cell senescence and aging in mammals by controlling mitochondrial dynamics and mitophagy

by Rizza, Salvatore, Cardaci, Simone, Montagna, Costanza, Di Giacomo, Giuseppina, De Zio, Daniela, Bordi, Matteo, Maiani, Emiliano, Campello, Silvia, Borreca, Antonella, Puca, Annibale A., Stamler, Jonathan S., Cecconi, Francesco, Filomeni, Giuseppe
Published in Proc Natl Acad Sci U S A (2018)

S-Nitrosoglutathione Reductase Deficiency-Induced S-Nitrosylation Results in Neuromuscular Dysfunction

by Montagna, Costanza, Di Giacomo, Giuseppina, Rizza, Salvatore, Cardaci, Simone, Ferraro, Elisabetta, Grumati, Paolo, De Zio, Daniela, Maiani, Emiliano, Muscoli, Carolina, Lauro, Filomena, Ilari, Sara, Bernardini, Sergio, Cannata, Stefano, Gargioli, Cesare, Ciriolo, Maria R., Cecconi, Francesco, Bonaldo, Paolo, Filomeni, Giuseppe
Published 2014

Fumarate induces redox-dependent senescence by modifying glutathione metabolism

by Zheng, Liang, Cardaci, Simone, Jerby, Livnat, MacKenzie, Elaine D., Sciacovelli, Marco, Johnson, T. Isaac, Gaude, Edoardo, King, Ayala, Leach, Joshua D. G., Edrada-Ebel, RuAngelie, Hedley, Ann, Morrice, Nicholas A., Kalna, Gabriela, Blyth, Karen, Ruppin, Eytan, Frezza, Christian, Gottlieb, Eyal
Published in Nat Commun (2015)

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

by Cardaci, Simone, Zheng, Liang, MacKay, Gillian, van den Broek, Niels J.F., MacKenzie, Elaine D., Nixon, Colin, Stevenson, David, Tumanov, Sergey, Bulusu, Vinay, Kamphorst, Jurre J., Vazquez, Alexei, Fleming, Stewart, Schiavi, Francesca, Kalna, Gabriela, Blyth, Karen, Strathdee, Douglas, Gottlieb, Eyal
Published in Nat Cell Biol (2015)

Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells

by Godoy, Luiz C., Muñoz-Pinedo, Cristina, Castro, Laura, Cardaci, Simone, Schonhoff, Christopher M., King, Michael, Tórtora, Verónica, Marín, Mónica, Miao, Qian, Jiang, Jian Fei, Kapralov, Alexandr, Jemmerson, Ronald, Silkstone, Gary G., Patel, Jinal N., Evans, James E., Wilson, Michael T., Green, Douglas R., Kagan, Valerian E., Radi, Rafael, Mannick, Joan B.
Published 2009

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

by Sciacovelli, Marco, Gonçalves, Emanuel, Isaac Johnson, Timothy, Roberto Zecchini, Vincent, da Costa, Ana Sofia Henriques, Gaude, Edoardo, Vercauteren Drubbel, Alizee, Julian Theobald, Sebastian, Abbo, Sandra, Tran, Maxine, Rajeeve, Vinothini, Cardaci, Simone, Foster, Sarah, Yun, Haiyang, Cutillas, Pedro, Warren, Anne, Gnanapragasam, Vincent, Gottlieb, Eyal, Franze, Kristian, Huntly, Brian, Richard Maher, Eamonn, Henry Maxwell, Patrick, Saez-Rodriguez, Julio, Frezza, Christian
Published in Nature (2016)