Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

Succinate dehydrogenase (SDH) is a hetero-tetrameric nuclear-encoded complex responsible for the oxidation of succinate to fumarate in the tricarboxylic acid (TCA) cycle. Loss-of-function mutations in any of the SDH genes are associated with cancer formation. However, the impact of SDH loss on cell...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Cell Biol
Main Authors: Cardaci, Simone, Zheng, Liang, MacKay, Gillian, van den Broek, Niels J.F., MacKenzie, Elaine D., Nixon, Colin, Stevenson, David, Tumanov, Sergey, Bulusu, Vinay, Kamphorst, Jurre J., Vazquez, Alexei, Fleming, Stewart, Schiavi, Francesca, Kalna, Gabriela, Blyth, Karen, Strathdee, Douglas, Gottlieb, Eyal
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591470/
https://ncbi.nlm.nih.gov/pubmed/26302408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3233
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados