Preclinical Predictors of Anticancer Drug Efficacy: Critical Assessment with Emphasis on Whether Nanomolar Potency Should Be Required of Candidate Agents

Por Wong, C. C., Cheng, Ka-Wing, Rigas, Basil
Publicado em 2012

The in vitro metabolism of phospho-sulindac amide, a novel potential anticancer agent

Por Xie, Gang, Cheng, Ka-Wing, Huang, Liqun, Rigas, Basil
Publicado em 2014

Comparative in vitro metabolism of phospho-tyrosol-indomethacin by mice, rats and humans

Por Xie, Gang, Zhou, Dingying, Cheng, Ka-Wing, Wong, Chi C., Rigas, Basil
Publicado em 2013

A Hetero-Photoautotrophic Two-Stage Cultivation Process for Production of Fucoxanthin by the Marine Diatom Nitzschia laevis

Por Lu, Xue, Sun, Han, Zhao, Weiyang, Cheng, Ka-Wing, Chen, Feng, Liu, Bin
Publicado no Mar Drugs (2018)

Curcumin enhances the lung cancer chemopreventive efficacy of phospho-sulindac by improving its pharmacokinetics

Por CHENG, KA-WING, WONG, CHI C., MATTHEOLABAKIS, GEORGE, XIE, GANG, HUANG, LIQUN, RIGAS, BASIL
Publicado em 2013

Topically Applied Phospho-Sulindac Hydrogel is Efficacious and Safe in the Treatment of Experimental Arthritis in Rats

Por Mattheolabakis, George, Mackenzie, Gerardo G., Huang, Liqun, Ouyang, Nengtai, Cheng, Ka Wing, Rigas, Basil
Publicado no Pharm Res (2013)

Regioselective oxidation of phospho-NSAIDs by human cytochrome P450 and flavin monooxygenase isoforms: implications for their pharmacokinetic properties and safety

Por Xie, Gang, Wong, Chi C, Cheng, Ka-Wing, Huang, Liqun, Constantinides, Panayiotis P, Rigas, Basil
Publicado em 2012

In Vitro and In Vivo Metabolic Studies of Phospho-aspirin (MDC-22)

Por Xie, Gang, Wong, Chi C., Cheng, Ka-Wing, Huang, Liqun, Constantinides, Panayiotis P., Rigas, Basil
Publicado em 2012

Phosphosulindac (OXT-328) selectively targets breast cancer stem cells in vitro and in human breast cancer xenografts

Por Zhu, Caihua, Cheng, Ka-Wing, Ouyang, Nengtai, Huang, Liqun, Sun, Yu, Constantinides, Panayiotis P., Rigas, Basil
Publicado em 2012

Topical phospho-sulindac (OXT-328) is effective in the treatment of non-melanoma skin cancer

Por CHENG, KA WING, MATTHEOLABAKIS, GEORGE, WONG, CHI C., OUYANG, NENGTAI, HUANG, LIQUN, CONSTANTINIDES, PANAYIOTIS P., RIGAS, BASIL
Publicado em 2012

Carboxylesterases 1 and 2 Hydrolyze Phospho-Nonsteroidal Anti-Inflammatory Drugs: Relevance to Their Pharmacological Activity

Por Wong, Chi C., Cheng, Ka-Wing, Xie, Gang, Zhou, Dingying, Zhu, Cai-Hua, Constantinides, Panayiotis P., Rigas, Basil
Publicado em 2012

Phospho-NSAIDs have enhanced efficacy in mice lacking plasma carboxylesterase: Implications for their clinical pharmacology

Por Wong, Chi C., Cheng, Ka-Wing, Papayannis, Ioannis, Mattheolabakis, George, Huang, Liqun, Xie, Gang, Ouyang, Nengtai, Rigas, Basil
Publicado no Pharm Res (2014)

Phospho-sulindac (OXT-328) Inhibits the Growth of Human Lung Cancer Xenografts in Mice: Enhanced Efficacy and Mitochondria Targeting by Its Formulation in Solid Lipid Nanoparticles

Por Zhu, Rongrong, Cheng, Ka-Wing, Mackenzie, Gerardo, Huang, Liqun, Sun, Yu, Xie, Gang, Vrankova, Kveta, Rigas, Basil, Constantinides, Panayiotis P.
Publicado em 2012

Aerosol Administration of Phospho-sulindac Inhibits Lung Tumorigenesis

Por Cheng, Ka Wing, Wong, Chi C, Alston, Ninche, Mackenzie, Gerardo G, Huang, Liqun, Ouyang, Nengtai, Xie, Gang, Wiedmann, Timothy, Rigas, Basil
Publicado em 2013

Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: an effect mediated by EGFR inhibition, p53 acetylation and oxidative stress

Por Huang, Liqun, Wong, Chi C, Mackenzie, Gerardo G, Sun, Yu, Cheng, Ka Wing, Vrankova, Kvetoslava, Alston, Ninche, Ouyang, Nengtai, Rigas, Basil
Publicado em 2014

6-C-(E-phenylethenyl)-Naringenin Suppresses Colorectal Cancer Growth by Inhibiting Cyclooxygenase-1

Por Li, Haitao, Zhu, Feng, Chen, Hanyong, Cheng, Ka Wing, Zykova, Tatyana, Oi, Naomi, Lubet, Ronald A., Bode, Ann M., Wang, Mingfu, Dong, Zigang
Publicado em 2013