When Clocks Go Bad: Neurobehavioural Consequences of Disrupted Circadian Timing

Por Barnard, Alun R., Nolan, Patrick M.
Publicado em 2008

Gene Therapy for Choroideremia Using an Adeno-Associated Viral (AAV) Vector

Por Barnard, Alun R., Groppe, Markus, MacLaren, Robert E.
Publicado no Cold Spring Harb Perspect Med (2015)


Gene Therapy for Color Blindness

Por Hassall, Mark M., Barnard, Alun R., MacLaren, Robert E.
Publicado no Yale J Biol Med (2017)

Rescue of the Stargardt phenotype in Abca4 knockout mice through inhibition of vitamin A dimerization

Por Charbel Issa, Peter, Barnard, Alun R., Herrmann, Philipp, Washington, Ilyas, MacLaren, Robert E.
Publicado no Proc Natl Acad Sci U S A (2015)

Inclusion of the Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances AAV2-Driven Transduction of Mouse and Human Retina

Por Patrício, Maria I., Barnard, Alun R., Orlans, Harry O., McClements, Michelle E., MacLaren, Robert E.
Publicado no Mol Ther Nucleic Acids (2017)

Retinal Pigment Epithelium Defects Accelerate Photoreceptor Degeneration in Cell Type–Specific Knockout Mouse Models of Choroideremia

Por Tolmachova, Tanya, Wavre-Shapton, Silene T., Barnard, Alun R., MacLaren, Robert E., Futter, Clare E., Seabra, Miguel C.
Publicado em 2010

Impact of Vital Dyes on Cell Viability and Transduction Efficiency of AAV Vectors Used in Retinal Gene Therapy Surgery: An In Vitro and In Vivo Analysis

Por Salvetti, Anna P., Patrício, Maria I., Barnard, Alun R., Orlans, Harry O., Hickey, Doron G., MacLaren, Robert E.
Publicado no Transl Vis Sci Technol (2017)

Non-Image-Forming Light Driven Functions Are Preserved in a Mouse Model of Autosomal Dominant Optic Atrophy

Por Perganta, Georgia, Barnard, Alun R., Katti, Christiana, Vachtsevanos, Athanasios, Douglas, Ron H., MacLaren, Robert E., Votruba, Marcela, Sekaran, Sumathi
Publicado em 2013

Optimization of In Vivo Confocal Autofluorescence Imaging of the Ocular Fundus in Mice and Its Application to Models of Human Retinal Degeneration

Por Issa, Peter Charbel, Singh, Mandeep S., Lipinski, Daniel M., Chong, Ngaihang V., Delori, François C., Barnard, Alun R., MacLaren, Robert E.
Publicado em 2012

Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation

Por Singh, Mandeep S., Charbel Issa, Peter, Butler, Rachel, Martin, Chris, Lipinski, Daniel M., Sekaran, Sumathi, Barnard, Alun R., MacLaren, Robert E.
Publicado em 2013

Fundus Autofluorescence in the Abca4(−/−) Mouse Model of Stargardt Disease—Correlation With Accumulation of A2E, Retinal Function, and Histology

Por Charbel Issa, Peter, Barnard, Alun R., Singh, Mandeep S., Carter, Emma, Jiang, Zhichun, Radu, Roxana A., Schraermeyer, Ulrich, MacLaren, Robert E.
Publicado em 2013

CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa

Por Lipinski, Daniel M, Barnard, Alun R, Singh, Mandeep S, Martin, Chris, Lee, Edward J, Davies, Wayne I L, MacLaren, Robert E
Publicado no Mol Ther (2015)

Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion

Por Singh, Mandeep S., Balmer, Jasmin, Barnard, Alun R., Aslam, Sher A., Moralli, Daniela, Green, Catherine M., Barnea-Cramer, Alona, Duncan, Isabel, MacLaren, Robert E.
Publicado no Nat Commun (2016)

Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo

Por Tolmachova, Tanya, Tolmachov, Oleg E., Barnard, Alun R., de Silva, Samantha R., Lipinski, Daniel M., Walker, Nathan J., MacLaren, Robert E., Seabra, Miguel C.
Publicado em 2013

Mouse Slc9a8 Mutants Exhibit Retinal Defects Due to Retinal Pigmented Epithelium Dysfunction

Por Jadeja, Shalini, Barnard, Alun R., McKie, Lisa, Cross, Sally H., White, Jacqueline K., Robertson, Morag, Budd, Peter S., MacLaren, Robert E., Jackson, Ian J.
Publicado no Invest Ophthalmol Vis Sci (2015)

Characterization of a Dominant Cone Degeneration in a Green Fluorescent Protein–Reporter Mouse with Disruption of Loci Associated with Human Dominant Retinal Dystrophy

Por Lipinski, Daniel M., Yusuf, Mohammed, Barnard, Alun R., Damant, Christopher, Issa, Peter Charbel, Singh, Mandeep S., Lee, Edward, Davies, Wayne L., Volpi, Emanuela V., MacLaren, Robert E.
Publicado em 2011

Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice

Por Barnea-Cramer, Alona O., Wang, Wei, Lu, Shi-Jiang, Singh, Mandeep S., Luo, Chenmei, Huo, Hongguang, McClements, Michelle E., Barnard, Alun R., MacLaren, Robert E., Lanza, Robert
Publicado no Sci Rep (2016)

Assessment of Tropism and Effectiveness of New Primate-Derived Hybrid Recombinant AAV Serotypes in the Mouse and Primate Retina

Por Charbel Issa, Peter, De Silva, Samantha R., Lipinski, Daniel M., Singh, Mandeep S., Mouravlev, Alexandre, You, Qisheng, Barnard, Alun R., Hankins, Mark W., During, Matthew J., MacLaren, Robert E.
Publicado em 2013

Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4(-/-) mouse and bipolar cells in the rd1 mouse and human retina ex-vivo

Por De Silva, Samantha R., Charbel Issa, Peter, Singh, Mandeep S., Lipinski, Daniel M., Barnea-Cramer, Alona O., Walker, Nathan J., Barnard, Alun R., Hankins, Mark W., MacLaren, Robert E.
Publicado no Gene Ther (2016)

Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking

Por Militi, Stefania, Maywood, Elizabeth S., Sandate, Colby R., Chesham, Johanna E., Barnard, Alun R., Parsons, Michael J., Vibert, Jennifer L., Joynson, Greg M., Partch, Carrie L., Hastings, Michael H., Nolan, Patrick M.
Publicado no Proc Natl Acad Sci U S A (2016)