Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity

ανά Fell, Jay B., Fischer, John P., Baer, Brian R., Ballard, Joshua, Blake, James F., Bouhana, Karyn, Brandhuber, Barbara J., Briere, David M., Burgess, Laurence E., Burkard, Michael R., Chiang, Harrah, Chicarelli, Mark J., Davidson, Kevin, Gaudino, John J., Hallin, Jill, Hanson, Lauren, Hee, Kenneth, Hicken, Erik J., Hinklin, Ronald J., Marx, Matthew A., Mejia, Macedonio J., Olson, Peter, Savechenkov, Pavel, Sudhakar, Niranjan, Tang, Tony P., Vigers, Guy P., Zecca, Henry, Christensen, James G.
Τόπος έκδοσης ACS Med Chem Lett (2018)

RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies

ανά Solomon, Benjamin J., Tan, Lavinia, Lin, Jessica J., Wong, Stephen Q., Hollizeck, Sebastian, Ebata, Kevin, Tuch, Brian B., Yoda, Satoshi, Gainor, Justin F., Sequist, Lecia V., Oxnard, Geoffrey R., Gautschi, Oliver, Drilon, Alexander, Subbiah, Vivek, Khoo, Christine, Zhu, Edward Y., Nguyen, Michele, Henry, Dahlia, Condroski, Kevin R., Kolakowski, Gabrielle R., Gomez, Eliana, Ballard, Joshua, Metcalf, Andrew T., Blake, James F., Dawson, Sarah-Jane, Blosser, Wayne, Stancato, Louis F., Brandhuber, Barbara J., Andrews, Steve, Robinson, Bruce G., Rothenberg, S. Michael
Τόπος έκδοσης J Thorac Oncol (2020)

The KRAS(G12C) Inhibitor, MRTX849, Provides Insight Toward Therapeutic Susceptibility of KRAS Mutant Cancers in Mouse Models and Patients

ανά Hallin, Jill, Engstrom, Lars D., Hargis, Lauren, Calinisan, Andrew, Aranda, Ruth, Briere, David M., Sudhakar, Niranjan, Bowcut, Vickie, Baer, Brian R., Ballard, Joshua A., Burkard, Michael R., Fell, Jay B., Fischer, John P., Vigers, Guy P., Xue, Yaohua, Gatto, Sole, Fernandez-Banet, Julio, Pavlicek, Adam, Velastagui, Karen, Chao, Richard C., Barton, Jeremy, Pierobon, Mariaelena, Baldelli, Elisa, Petricoin, Emanuel F., Cassidy, Douglas P., Marx, Matthew A., Rybkin, Igor I., Johnson, Melissa L., Ou, Sai-Hong Ignatius, Lito, Piro, Papadopoulos, Kyriakos P., Jänne, Pasi A., Olson, Peter, Christensen, James G.
Τόπος έκδοσης Cancer Discov (2019)

A global benchmark study using affinity-based biosensors

ανά Rich, Rebecca L., Papalia, Giuseppe A., Flynn, Peter J., Furneisen, Jamie, Quinn, John, Klein, Joshua S., Katsamba, Phini S., Waddell, M. Brent, Scott, Michael, Thompson, Joshua, Berlier, Judie, Corry, Schuyler, Baltzinger, Mireille, Zeder-Lutz, Gabrielle, Schoenemann, Andreas, Clabbers, Anca, Wieckowski, Sebastien, Murphy, Mary M., Page, Phillip, Ryan, Thomas E., Duffner, Jay, Ganguly, Tanmoy, Corbin, John, Gautam, Satyen, Anderluh, Gregor, Bavdek, Andrej, Reichmann, Dana, Yadav, Satya P., Hommema, Eric, Pol, Ewa, Drake, Andrew, Klakamp, Scott, Chapman, Trevor, Kernaghan, Dawn, Miller, Ken, Schuman, Jason, Lindquist, Kevin, Herlihy, Kara, Murphy, Michael B., Bohnsack, Richard, Andrien, Bruce, Brandani, Pietro, Terwey, Danny, Millican, Rohn, Darling, Ryan J., Wang, Liann, Carter, Quincy, Dotzlaf, Joe, Lopez-Sagaseta, Jacinto, Campbell, Islay, Torreri, Paola, Hoos, Sylviane, England, Patrick, Liu, Yang, Abdiche, Yasmina, Malashock, Daniel, Pinkerton, Alanna, Wong, Melanie, Lafer, Eileen, Hinck, Cynthia, Thompson, Kevin, Primo, Carmelo Di, Joyce, Alison, Brooks, Jonathan, Torta, Federico, Bagge Hagel, Anne Birgitte, Krarup, Janus, Pass, Jesper, Ferreira, Monica, Shikov, Sergei, Mikolajczyk, Malgorzata, Abe, Yuki, Barbato, Gaetano, Giannetti, Anthony M., Krishnamoorthy, Ganeshram, Beusink, Bianca, Satpaev, Daulet, Tsang, Tiffany, Fang, Eric, Partridge, James, Brohawn, Stephen, Horn, James, Pritsch, Otto, Obal, Gonzalo, Nilapwar, Sanjay, Busby, Ben, Gutierrez-Sanchez, Gerardo, Gupta, Ruchira Das, Canepa, Sylvie, Witte, Krista, Nikolovska-Coleska, Zaneta, Cho, Yun Hee, D’Agata, Roberta, Schlick, Kristian, Calvert, Rosy, Munoz, Eva M., Hernaiz, Maria Jose, Bravman, Tsafir, Dines, Monica, Yang, Min-Hsiang, Puskas, Agnes, Boni, Erica, Li, Jiejin, Wear, Martin, Grinberg, Asya, Baardsnes, Jason, Dolezal, Olan, Gainey, Melicia, Anderson, Henrik, Peng, Jinlin, Lewis, Mark, Spies, Peter, Trinh, Quyhn, Bibikov, Sergei, Raymond, Jill, Yousef, Mohammed, Chandrasekaran, Vidya, Feng, Yuguo, Emerick, Anne, Mundodo, Suparna, Guimaraes, Rejane, McGirr, Katy, Li, Yue-Ji, Hughes, Heather, Mantz, Hubert, Skrabana, Rostislav, Witmer, Mark, Ballard, Joshua, Martin, Loic, Skladal, Petr, Korza, George, Laird-Offringa, Ite, Lee, Charlene S., Khadir, Abdelkrim, Podlaski, Frank, Neuner, Phillippe, Rothacker, Julie, Rafique, Ashique, Dankbar, Nico, Kainz, Peter, Gedig, Erk, Vuyisich, Momchilo, Boozer, Christina, Ly, Nguyen, Toews, Mark, Uren, Aykut, Kalyuzhniy, Oleksandr, Lewis, Kenneth, Chomey, Eugene, Pak, Brian J., Myszka, David G.
Έκδοση 2008