Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity

by Fell, Jay B., Fischer, John P., Baer, Brian R., Ballard, Joshua, Blake, James F., Bouhana, Karyn, Brandhuber, Barbara J., Briere, David M., Burgess, Laurence E., Burkard, Michael R., Chiang, Harrah, Chicarelli, Mark J., Davidson, Kevin, Gaudino, John J., Hallin, Jill, Hanson, Lauren, Hee, Kenneth, Hicken, Erik J., Hinklin, Ronald J., Marx, Matthew A., Mejia, Macedonio J., Olson, Peter, Savechenkov, Pavel, Sudhakar, Niranjan, Tang, Tony P., Vigers, Guy P., Zecca, Henry, Christensen, James G.
Published in ACS Med Chem Lett (2018)

The KRAS(G12C) Inhibitor, MRTX849, Provides Insight Toward Therapeutic Susceptibility of KRAS Mutant Cancers in Mouse Models and Patients

by Hallin, Jill, Engstrom, Lars D., Hargis, Lauren, Calinisan, Andrew, Aranda, Ruth, Briere, David M., Sudhakar, Niranjan, Bowcut, Vickie, Baer, Brian R., Ballard, Joshua A., Burkard, Michael R., Fell, Jay B., Fischer, John P., Vigers, Guy P., Xue, Yaohua, Gatto, Sole, Fernandez-Banet, Julio, Pavlicek, Adam, Velastagui, Karen, Chao, Richard C., Barton, Jeremy, Pierobon, Mariaelena, Baldelli, Elisa, Petricoin, Emanuel F., Cassidy, Douglas P., Marx, Matthew A., Rybkin, Igor I., Johnson, Melissa L., Ou, Sai-Hong Ignatius, Lito, Piro, Papadopoulos, Kyriakos P., Jänne, Pasi A., Olson, Peter, Christensen, James G.
Published in Cancer Discov (2019)