Finding new medicines to fight CF: multiple steps of a success story

Yazar: Amaral, Margarida D
Baskı/Yayın Bilgisi 2012

Most F508del-CFTR Is Targeted to Degradation at an Early Folding Checkpoint and Independently of Calnexin

Yazar: Farinha, Carlos M., Amaral, Margarida D.
Baskı/Yayın Bilgisi 2005

Hallmarks of Therapeutic Management of the Cystic Fibrosis Functional Landscape

Yazar: Amaral, Margarida D., Balch, William E.
Yayımlandı J Cyst Fibros (2015)

What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer?

Yazar: Amaral, Margarida D., Quaresma, Margarida C., Pankonien, Ines
Yayımlandı Int J Mol Sci (2020)

Neuronal Reprograming of Protein Homeostasis by Calcium-Dependent Regulation of the Heat Shock Response

Yazar: Silva, M. Catarina, Amaral, Margarida D., Morimoto, Richard I.
Baskı/Yayın Bilgisi 2013

Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies

Yazar: Clarke, Luka A, Sousa, Lisete, Barreto, Celeste, Amaral, Margarida D
Baskı/Yayın Bilgisi 2013

Personalized Medicine Based on Nasal Epithelial Cells: Comparative Studies with Rectal Biopsies and Intestinal Organoids

Yazar: Silva, Iris A. L., Railean, Violeta, Duarte, Aires, Amaral, Margarida D.
Yayımlandı J Pers Med (2021)

The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator by Hs...

Yazar: Farinha, Carlos M, Nogueira, Paulo, Mendes, Filipa, Penque, Deborah, Amaral, Margarida D
Baskı/Yayın Bilgisi 2002

Impact of KLF4 on Cell Proliferation and Epithelial Differentiation in the Context of Cystic Fibrosis

Yazar: Sousa, Luís, Pankonien, Ines, Simões, Filipa B., Chanson, Marc, Amaral, Margarida D.
Yayımlandı Int J Mol Sci (2020)

Increased efficacy of VX-809 in different cellular systems results from an early stabilization effect of F508del-CFTR

Yazar: Farinha, Carlos M, Sousa, Marisa, Canato, Sara, Schmidt, André, Uliyakina, Inna, Amaral, Margarida D
Yayımlandı Pharmacol Res Perspect (2015)

KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway

Yazar: Sousa, Luis, Pankonien, Ines, Clarke, Luka A, Silva, Iris, Kunzelmann, Karl, Amaral, Margarida D
Yayımlandı Cells (2020)

Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells

Yazar: Garcia, Susana M., Casanueva, M. Olivia, Silva, M. Catarina, Amaral, Margarida D., Morimoto, Richard I.
Baskı/Yayın Bilgisi 2007

Regulation of the Epithelial Na(+) Channel by the Protein Kinase CK2

Yazar: Bachhuber, Tanja, Almaça, Joana, Aldehni, Fadi, Mehta, Anil, Amaral, Margarida D., Schreiber, Rainer, Kunzelmann, Karl
Baskı/Yayın Bilgisi 2008

A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network

Yazar: Silva, M. Catarina, Fox, Susan, Beam, Monica, Thakkar, Happy, Amaral, Margarida D., Morimoto, Richard I.
Baskı/Yayın Bilgisi 2011

Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant

Yazar: Matos, Ana M., Pinto, Francisco R., Barros, Patrícia, Amaral, Margarida D., Pepperkok, Rainer, Matos, Paulo
Yayımlandı J Biol Chem (2019)

Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation

Yazar: Pinto, Madalena C., Schreiber, Rainer, Lerias, Joana, Ousingsawat, Jiraporn, Duarte, Aires, Amaral, Margarida, Kunzelmann, Karl
Yayımlandı Cells (2020)

Pharmacological Modulation of Ion Channels for the Treatment of Cystic Fibrosis

Yazar: Pinto, Madalena C, Silva, Iris A L, Figueira, Miriam F, Amaral, Margarida D, Lopes-Pacheco, Miquéias
Yayımlandı J Exp Pharmacol (2021)

Antagonistic Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Cell Surface Expression by Protein Kinases WNK4 and Spleen Tyrosine Kinase

Yazar: Mendes, Ana Isabel, Matos, Paulo, Moniz, Sónia, Luz, Simão, Amaral, Margarida D., Farinha, Carlos M., Jordan, Peter
Baskı/Yayın Bilgisi 2011

LMTK2-mediated Phosphorylation Regulates CFTR Endocytosis in Human Airway Epithelial Cells

Yazar: Luz, Simão, Cihil, Kristine M., Brautigan, David L., Amaral, Margarida D., Farinha, Carlos M., Swiatecka-Urban, Agnieszka
Baskı/Yayın Bilgisi 2014

A Mathematical Model of the Phosphoinositide Pathway

Yazar: Olivença, Daniel V., Uliyakina, Inna, Fonseca, Luis L., Amaral, Margarida D., Voit, Eberhard O., Pinto, Francisco R.
Yayımlandı Sci Rep (2018)