Finding new medicines to fight CF: multiple steps of a success story

gan Amaral, Margarida D
Cyhoeddwyd 2012

Most F508del-CFTR Is Targeted to Degradation at an Early Folding Checkpoint and Independently of Calnexin

gan Farinha, Carlos M., Amaral, Margarida D.
Cyhoeddwyd 2005

Hallmarks of Therapeutic Management of the Cystic Fibrosis Functional Landscape

gan Amaral, Margarida D., Balch, William E.
Cyhoeddwyd yn J Cyst Fibros (2015)

What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer?

gan Amaral, Margarida D., Quaresma, Margarida C., Pankonien, Ines
Cyhoeddwyd yn Int J Mol Sci (2020)

Neuronal Reprograming of Protein Homeostasis by Calcium-Dependent Regulation of the Heat Shock Response

gan Silva, M. Catarina, Amaral, Margarida D., Morimoto, Richard I.
Cyhoeddwyd 2013

Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies

gan Clarke, Luka A, Sousa, Lisete, Barreto, Celeste, Amaral, Margarida D
Cyhoeddwyd 2013

Personalized Medicine Based on Nasal Epithelial Cells: Comparative Studies with Rectal Biopsies and Intestinal Organoids

gan Silva, Iris A. L., Railean, Violeta, Duarte, Aires, Amaral, Margarida D.
Cyhoeddwyd yn J Pers Med (2021)

The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator by Hs...

gan Farinha, Carlos M, Nogueira, Paulo, Mendes, Filipa, Penque, Deborah, Amaral, Margarida D
Cyhoeddwyd 2002

Impact of KLF4 on Cell Proliferation and Epithelial Differentiation in the Context of Cystic Fibrosis

gan Sousa, Luís, Pankonien, Ines, Simões, Filipa B., Chanson, Marc, Amaral, Margarida D.
Cyhoeddwyd yn Int J Mol Sci (2020)

Increased efficacy of VX-809 in different cellular systems results from an early stabilization effect of F508del-CFTR

gan Farinha, Carlos M, Sousa, Marisa, Canato, Sara, Schmidt, André, Uliyakina, Inna, Amaral, Margarida D
Cyhoeddwyd yn Pharmacol Res Perspect (2015)

KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway

gan Sousa, Luis, Pankonien, Ines, Clarke, Luka A, Silva, Iris, Kunzelmann, Karl, Amaral, Margarida D
Cyhoeddwyd yn Cells (2020)

Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells

gan Garcia, Susana M., Casanueva, M. Olivia, Silva, M. Catarina, Amaral, Margarida D., Morimoto, Richard I.
Cyhoeddwyd 2007

Regulation of the Epithelial Na(+) Channel by the Protein Kinase CK2

gan Bachhuber, Tanja, Almaça, Joana, Aldehni, Fadi, Mehta, Anil, Amaral, Margarida D., Schreiber, Rainer, Kunzelmann, Karl
Cyhoeddwyd 2008

A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network

gan Silva, M. Catarina, Fox, Susan, Beam, Monica, Thakkar, Happy, Amaral, Margarida D., Morimoto, Richard I.
Cyhoeddwyd 2011

Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant

gan Matos, Ana M., Pinto, Francisco R., Barros, Patrícia, Amaral, Margarida D., Pepperkok, Rainer, Matos, Paulo
Cyhoeddwyd yn J Biol Chem (2019)

Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation

gan Pinto, Madalena C., Schreiber, Rainer, Lerias, Joana, Ousingsawat, Jiraporn, Duarte, Aires, Amaral, Margarida, Kunzelmann, Karl
Cyhoeddwyd yn Cells (2020)

Pharmacological Modulation of Ion Channels for the Treatment of Cystic Fibrosis

gan Pinto, Madalena C, Silva, Iris A L, Figueira, Miriam F, Amaral, Margarida D, Lopes-Pacheco, Miquéias
Cyhoeddwyd yn J Exp Pharmacol (2021)

Antagonistic Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Cell Surface Expression by Protein Kinases WNK4 and Spleen Tyrosine Kinase

gan Mendes, Ana Isabel, Matos, Paulo, Moniz, Sónia, Luz, Simão, Amaral, Margarida D., Farinha, Carlos M., Jordan, Peter
Cyhoeddwyd 2011

LMTK2-mediated Phosphorylation Regulates CFTR Endocytosis in Human Airway Epithelial Cells

gan Luz, Simão, Cihil, Kristine M., Brautigan, David L., Amaral, Margarida D., Farinha, Carlos M., Swiatecka-Urban, Agnieszka
Cyhoeddwyd 2014

A Mathematical Model of the Phosphoinositide Pathway

gan Olivença, Daniel V., Uliyakina, Inna, Fonseca, Luis L., Amaral, Margarida D., Voit, Eberhard O., Pinto, Francisco R.
Cyhoeddwyd yn Sci Rep (2018)