Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain

by Bigalke, Janna M., Aibara, Shintaro, Roth, Robert, Dahl, Göran, Gordon, Euan, Dorbéus, Sarah, Amunts, A., Sandmark, Jenny
Published in Sci Adv (2019)

Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands

by Belorusova, Anna Y., Evertsson, Emma, Hovdal, Daniel, Sandmark, Jenny, Bratt, Emma, Maxvall, Ingela, Schulman, Ira G., Åkerblad, Peter, Lindstedt, Eva-Lotte
Published in Commun Biol (2019)

Structure and biophysical characterization of the human full-length neurturin–GFRa2 complex: A role for heparan sulfate in signaling

by Sandmark, Jenny, Dahl, Göran, Öster, Linda, Xu, Bingze, Johansson, Patrik, Akerud, Tomas, Aagaard, Anna, Davidsson, Pia, Bigalke, Janna M., Winzell, Maria Sörhede, Rainey, G. Jonah, Roth, Robert G.
Published in J Biol Chem (2018)

Discovery of AZD2716: A Novel Secreted Phospholipase A(2) (sPLA(2)) Inhibitor for the Treatment of Coronary Artery Disease

by Giordanetto, Fabrizio, Pettersen, Daniel, Starke, Ingemar, Nordberg, Peter, Dahlström, Mikael, Knerr, Laurent, Selmi, Nidhal, Rosengren, Birgitta, Larsson, Lars-Olof, Sandmark, Jenny, Castaldo, Marie, Dekker, Niek, Karlsson, Ulla, Hurt-Camejo, Eva
Published in ACS Med Chem Lett (2016)

Creating Novel Activated Factor XI Inhibitors through Fragment Based Lead Generation and Structure Aided Drug Design

by Fjellström, Ola, Akkaya, Sibel, Beisel, Hans-Georg, Eriksson, Per-Olof, Erixon, Karl, Gustafsson, David, Jurva, Ulrik, Kang, Daiwu, Karis, David, Knecht, Wolfgang, Nerme, Viveca, Nilsson, Ingemar, Olsson, Thomas, Redzic, Alma, Roth, Robert, Sandmark, Jenny, Tigerström, Anna, Öster, Linda
Published in PLoS One (2015)

Design of Selective sPLA(2)-X Inhibitor (−)-2-{2-[Carbamoyl-6-(trifluoromethoxy)-1H-indol-1-yl]pyridine-2-yl}propanoic Acid

by Giordanetto, Fabrizio, Knerr, Laurent, Nordberg, Peter, Pettersen, Daniel, Selmi, Nidhal, Beisel, Hans-Georg, de la Motte, Hannah, Månsson, Åsa, Dahlström, Mikael, Broddefalk, Johan, Saarinen, Gabrielle, Klingegård, Fredrik, Hurt-Camejo, Eva, Rosengren, Birgitta, Wikström, Johannes, Wågberg, Maria, Brengdahl, Johan, Rohman, Mattias, Sandmark, Jenny, Åkerud, Tomas, Roth, Robert G., Jansen, Frank, Ahlqvist, Marie
Published in ACS Med Chem Lett (2018)

Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A(2) Type X (sPLA(2)-X) Inhibitors

by Knerr, Laurent, Giordanetto, Fabrizio, Nordberg, Peter, Pettersen, Daniel, Selmi, Nidhal, Beisel, Hans-Georg, de la Motte, Hannah, Olsson, Thomas, Perkins, Tim D. J., Herslöf, Margareta, Månsson, Åsa, Dahlström, Mikael, Starke, Ingemar, Broddefalk, Johan, Saarinen, Gabrielle, Klingegård, Fredrik, Hurt-Camejo, Eva, Rosengren, Birgitta, Brengdahl, Johan, Jansen, Frank, Rohman, Mattias, Sandmark, Jenny, Hallberg, Kenth, Åkerud, Tomas, Roth, Robert G., Ahlqvist, Marie
Published in ACS Med Chem Lett (2018)

Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function

by Sandmark, Jenny, Tigerström, Anna, Akerud, Tomas, Althage, Magnus, Antonsson, Thomas, Blaho, Stefan, Bodin, Cristian, Boström, Jonas, Chen, Yantao, Dahlén, Anders, Eriksson, Per-Olof, Evertsson, Emma, Fex, Tomas, Fjellström, Ola, Gustafsson, David, Herslöf, Margareta, Hicks, Ryan, Jarkvist, Emelie, Johansson, Carina, Kalies, Inge, Karlsson Svalstedt, Birgitta, Kartberg, Fredrik, Legnehed, Anne, Martinsson, Sofia, Moberg, Andreas, Ridderström, Marianne, Rosengren, Birgitta, Sabirsh, Alan, Thelin, Anders, Vinblad, Johanna, Wellner, Annika U., Xu, Bingze, Östlund-Lindqvist, Ann-Margret, Knecht, Wolfgang
Published in J Biol Chem (2020)