RNA interference as a therapeutic strategy for treating CNS disorders

Por Hoyer, Daniel, Dev, Kumlesh K.
Publicado no Drug Discov Today Ther Strateg (2006)

In-vitro blood-brain barrier models for drug screening and permeation studies: an overview

Por Bagchi, Sounak, Chhibber, Tanya, Lahooti, Behnaz, Verma, Angela, Borse, Vivek, Jayant, Rahul Dev
Publicado no Drug Des Devel Ther (2019)

Overcoming Compensatory Mechanisms toward Chronic Drug Administration to Ensure Long-Term, Sustainable Beneficial Effects

Por Ilan, Yaron
Publicado no Mol Ther Methods Clin Dev (2020)

Preclinical safety, pharmacokinetics, pharmacodynamics, and biodistribution studies with Ad35K++ protein: a novel rituximab cotherapeutic

Por Richter, Maximilian, Yumul, Roma, Saydaminova, Kamola, Wang, Hongjie, Gough, Michael, Baldessari, Audrey, Cattaneo, Roberto, Lee, Frank, Wang, Chung-Huei Katherine, Jang, Haishan, Astier, Anne, Gopal, Ajay, Carter, Darrick, Lieber, André
Publicado no Mol Ther Methods Clin Dev (2016)

A Novel Proteomic Method Reveals NLS Tagging of T-DM1 Contravenes Classical Nuclear Transport in a Model of HER2-Positive Breast Cancer

Por Lacasse, Vincent, Beaudoin, Simon, Jean, Steve, Leyton, Jeffrey V.
Publicado no Mol Ther Methods Clin Dev (2020)

AAV-Mediated CRISPR/Cas9 Gene Editing in Murine Phenylketonuria

Por Richards, Daelyn Y., Winn, Shelley R., Dudley, Sandra, Nygaard, Sean, Mighell, Taylor L., Grompe, Markus, Harding, Cary O.
Publicado no Mol Ther Methods Clin Dev (2019)

Deferoxamine mesylate improves splicing and GAA activity of the common c.-32-13T>G allele in late-onset PD patient fibroblasts

Por Buratti, Emanuele, Peruzzo, Paolo, Braga, Luca, Zanin, Irene, Stuani, Cristiana, Goina, Elisa, Romano, Maurizio, Giacca, Mauro, Dardis, Andrea
Publicado no Mol Ther Methods Clin Dev (2020)

In question: the scientific value of preclinical safety pharmacology and toxicology studies with cell-based therapies

Por Broichhausen, Christiane, Riquelme, Paloma, Ahrens, Norbert, Wege, Anja K, Koehl, Gudrun E, Schlitt, Hans J, Banas, Bernhard, Fändrich, Fred, Geissler, Edward K, Hutchinson, James A
Publicado no Mol Ther Methods Clin Dev (2014)

Emerging Issues in AAV-Mediated In Vivo Gene Therapy

Por Colella, Pasqualina, Ronzitti, Giuseppe, Mingozzi, Federico
Publicado no Mol Ther Methods Clin Dev (2017)

Efficient inhibition of tumor angiogenesis and growth by a synthetic peptide blocking S100A4-methionine aminopeptidase 2 interaction

Por Ochiya, Takahiro, Takenaga, Keizo, Asagiri, Masataka, Nakano, Kazumi, Satoh, Hitoshi, Watanabe, Toshiki, Imajoh-Ohmi, Shinobu, Endo, Hideya
Publicado no Mol Ther Methods Clin Dev (2015)

Conditionally replicating adenovirus prevents pluripotent stem cell–derived teratoma by specifically eliminating undifferentiated cells

Por Mitsui, Kaoru, Ide, Kanako, Takayama, Akiko, Wada, Tadahisa, Irie, Rie, Kosai, Ken-ichiro
Publicado no Mol Ther Methods Clin Dev (2015)

Therapeutic Targeting of Protein Kinase CK2 Gene Expression in Feline Oral Squamous Cell Carcinoma: A Naturally Occurring Large-Animal Model of Head and Neck Cancer(†)

Por Cannon, Claire M., Trembley, Janeen H., Kren, Betsy T., Unger, Gretchen M., O'Sullivan, M. Gerard, Cornax, Ingrid, Modiano, Jaime F., Ahmed, Khalil
Publicado no Hum Gene Ther Clin Dev (2017)

Protein Delivery of Cell-Penetrating Zinc-Finger Activators Stimulates Latent HIV-1-Infected Cells

Por Perdigão, Pedro R.L., Cunha-Santos, Catarina, Barbas, Carlos F., Santa-Marta, Mariana, Goncalves, Joao
Publicado no Mol Ther Methods Clin Dev (2020)

Human Umbilical Tissue-Derived Cells Secrete Soluble VEGFR1 and Inhibit Choroidal Neovascularization

Por Cao, Jing, Yang, Rong, Smith, Taylor E., Evans, Stephanie, McCollum, Gary W., Pomerantz, Steven C., Petley, Theodore, Harris, Ian R., Penn, John S.
Publicado no Mol Ther Methods Clin Dev (2019)

Constitutively active form of natriuretic peptide receptor 2 ameliorates experimental pulmonary arterial hypertension

Por Nawa, Nobutoshi, Ishida, Hidekazu, Katsuragi, Shinichi, Baden, Hiroki, Takahashi, Kunihiko, Higeno, Ryota, Torigoe, Fumiko, Mihara, Seiko, Narita, Jun, Miura, Kohji, Nakamura, Kazufumi, Kogaki, Shigetoyo, Ozono, Keiichi
Publicado no Mol Ther Methods Clin Dev (2016)