Resultados da pesquisa - ((drug dnaer) OR (drug dna)) ((devel ther) OR (novel ther))

141

Berberine reverses lapatinib resistance of HER2-positive breast cancer cells by increasing the level of ROS

Por Zhang, Ruohan, Qiao, Hongyu, Chen, Suning, Chen, Xu, Dou, Kefeng, Wei, Li, Zhang, Jian
Publicado no Cancer Biol Ther (2016)

“...Lapatinib, a novel tyrosine kinase inhibitor of HER2/EGFR, is used to treat HER2-positive breast...”
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142

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Pixantrone induces cell death through mitotic perturbations and subsequent aberrant cell divisions

Por Beeharry, Neil, Di Rora, Andrea Ghelli Luserna, Smith, Mitchell R, Yen, Timothy J
Publicado no Cancer Biol Ther (2015)

“...Pixantrone is a novel aza-anthracenedione active against aggressive lymphoma and is being evaluated...”
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143

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Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines

Por Youssef, Magdy M, Arafa, Reem K, Ismail, Mohamed A
Publicado no Drug Des Devel Ther (2016)

“... was investigated by determining their nuclease-like DNA degradation ability in addition to their antioxidant power...”
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144

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Halofuginone ameliorates inflammation in severe acute hepatitis B virus (HBV)-infected SD rats through AMPK activation

Por Zhan, Weili, Kang, Yanhong, Chen, Ning, Mao, Chongshan, Kang, Yi, Shang, Jia
Publicado no Drug Des Devel Ther (2017)

“... of serum hepatitis B e-antigen, hepatitis B surface antigen, and HBV DNA induced by HBV infection. HF also...”
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145

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Loss of Keap1 Function in Prostate Cancer Cells Causes Chemo- and Radio-resistance and Promotes Tumor Growth

Por Zhang, Ping, Singh, Anju, Yegnasubramanian, Srinivasan, Esopi, David, Kombairaju, Ponvijay, Bodas, Manish, Wu, Hailong, Bova, G. Steven, Biswal, Shyam
Publicado em 2010

“... to non-conservative amino acid substitutions in prostate cancer cells. We found novel transcriptional...”
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146

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A study on the hemocompatibility of dendronized chitosan derivatives in red blood cells

Por Zhou, Yanfang, Li, Jiemei, Lu, Fang, Deng, Junjie, Zhang, Jiahua, Fang, Peijie, Peng, Xinsheng, Zhou, Shu-Feng
Publicado no Drug Des Devel Ther (2015)

“... exhibited a better water solubility and enhanced plasmid DNA transfection efficiency. In this study, we...”
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147

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First-line treatment of apatinib in elderly patient of advanced gastric carcinoma: A case report of NGS-driven targeted therapy

Por Yang, Yan, Zhang, Wuqiong, Yao, Jinghao, Liu, Jing, Qin, Shukui, Wu, Qiong
Publicado no Cancer Biol Ther (2018)

“... elderly GC patient using next generation sequencing (NGS)-based tumor DNA analysis. Valuable gene variants...”
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148

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Identification of the serine biosynthesis pathway as a critical component of BRAF inhibitor resistance of melanoma, pancreatic, and non-small cell lung cancer cells

Por Ross, Kayleigh C., Andrews, Andrew J., Marion, Christopher D., Yen, Timothy J., Bhattacharjee, Vikram
Publicado no Mol Cancer Ther (2017)

“... downstream of serine synthesis, with methotrexate also displayed similar sensitization. Using the DNA...”
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149

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Prospects for antisense peptide nucleic acid (PNA) therapies for HIV

Por Pandey, Virendra N., Upadhyay, Alok, Chaubey, Binay
Publicado em 2009

“...Since the discovery and synthesis of a novel DNA mimic, peptide nucleic acid (PNA) in 1991, PNAs...”
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150

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A Smac mimetic augments the response of urothelial cancer cells to gemcitabine and cisplatin

Por Lee, Eugene K, Jinesh G, Goodwin, Laing, Naomi M, Choi, Woonyoung, McConkey, David J, Kamat, Ashish M
Publicado em 2013

“... cancer. However, despite initial response, many patients will relapse; therefore, novel salvage treatment...”
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151

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Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts

Por Donejko, Magdalena, Przylipiak, Andrzej, Rysiak, Edyta, Miltyk, Wojciech, Galicka, Elżbieta, Przylipiak, Jerzy, Zaręba, Ilona, Surazynski, Arkadiusz
Publicado no Drug Des Devel Ther (2015)

“.... MATERIALS AND METHODS: Collagen biosynthesis, activity of prolidase, DNA biosynthesis, and cytotoxicity were...”
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152

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Autophagy inhibition enhances RAD001-induced cytotoxicity in human bladder cancer cells

Por Lin, Ji-Fan, Lin, Yi-Chia, Yang, Shan-Che, Tsai, Te-Fu, Chen, Hung-En, Chou, Kuang-Yu, Hwang, Thomas I-Sheng
Publicado no Drug Des Devel Ther (2016)

“... by measurement of caspase 3/7 activity and DNA fragmentation in cells after treatment. RESULTS: Advanced bladder...”
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153

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Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells

Por Lin, Ji-Fan, Lin, Yi-Chia, Tsai, Te-Fu, Chen, Hung-En, Chou, Kuang-Yu, Hwang, Thomas I-Sheng
Publicado no Drug Des Devel Ther (2017)

“.../7 activity and DNA fragmentation. RESULTS: Cisplatin decreased cell viability and induced apoptosis...”
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154

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siRNA-based breast cancer therapy by suppressing 17β-hydroxysteroid dehydrogenase type 1 in an optimized xenograft cell and molecular biology model in vivo

Por Li, Fang, Zhu, ZhiHan, Xue, Man, He, WanHong, Zhang, Ting, Feng, LingLin, Lin, ShengXiang
Publicado no Drug Des Devel Ther (2019)

“.../LPD”, a PEGylated and modified liposome–polycation–DNA nanoparticle containing 17β-HSD1-siRNA...”
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155

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Caffeic acid phenethyl ester suppressed growth and metastasis of nasopharyngeal carcinoma cells by inactivating the NF-κB pathway

Por Liang, Yushan, Feng, Guofei, Wu, Liang, Zhong, Suhua, Gao, Xiaoyu, Tong, Yan, Cui, Wanmeng, Qin, Yongying, Xu, WenQing, Xiao, Xue, Zhang, Zhe, Huang, Guangwu, Zhou, Xiaoying
Publicado no Drug Des Devel Ther (2019)

“... measured by colony-formation assay. cDNA microarray analysis was used to determine differentially expressed...”
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156

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TMF inhibits miR-29a/Wnt/β-catenin signaling through upregulating Foxo3a activity in osteoarthritis chondrocytes

Por Huang, Xianhua, Chen, Zhixi, Shi, Weimei, Zhang, Rui, Li, Linfu, Liu, Hai, Wu, Longhuo
Publicado no Drug Des Devel Ther (2019)

“... expression, and protein expression were conducted. In addition, miR-29a mimics and pcDNA3.1(+)-Foxo3a vector...”
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157

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Id-1 Promotes Reendothelialization In The Early Phase After Vascular Injury Through Activation Of NFkB/survivin Signaling Pathway

Por Li, Wei, Du, Dayong, Li, Yuntian
Publicado no Drug Des Devel Ther (2019)

“... restenosis. Id1 (inhibitor of DNA binding/differentiation factor 1) plays an important role in promoting cell...”
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158

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Azacitidine in the management of patients with myelodysplastic syndromes

Por Khan, Cyrus, Pathe, Neeta, Fazal, Salman, Lister, John, Rossetti, James M.
Publicado em 2012

“... of irreversible DNA methlytransferase inhibitors such as azacitidine was investigated with promising outcomes...”
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159

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MENA confers resistance to paclitaxel in triple-negative breast cancer

Por Oudin, Madeleine J., Barbier, Lucie, Schäfer, Claudia, Kosciuk, Tatsiana, Miller, Miles A., Han, Sangyoon, Jonas, Oliver, Lauffenburger, Douglas A., Gertler, Frank B.
Publicado no Mol Cancer Ther (2016)

“... acquire resistance to this drug. The actin regulatory protein MENA, particularly its invasive isoform...”
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160

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Combined treatment with olmesartan medoxomil and amlodipine besylate attenuates atherosclerotic lesion progression in a model of advanced atherosclerosis

Por Sievers, Philipp, Uhlmann, Lorenz, Korkmaz-Icöz, Sevil, Fastner, Christian, Bea, Florian, Blessing, Erwin, Katus, Hugo A, Preusch, Michael R
Publicado no Drug Des Devel Ther (2015)

“.... Mice were sacrificed after 25 weeks of drug administration and perfused with formalin. Innominate...”
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