Resultados da pesquisa - ((drug (dosev OR dosed)) or (drug dose)) (devel or level) ther*

1

High-dose atorvastatin versus moderate dose on early vascular protection after ST-elevation myocardial infarction

Por Gavazzoni, Mara, Gorga, Elio, Derosa, Giuseppe, Maffioli, Pamela, Metra, Marco, Raddino, Riccardo
Publicado no Drug Des Devel Ther (2017)

“...BACKGROUND AND AIM: Clinical benefits of early high-dose statin therapy after acute coronary...”
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Dose-dependent effects of atorvastatin on myocardial infarction

Por Barbarash, Olga, Gruzdeva, Olga, Uchasova, Evgenya, Belik, Ekaterina, Dyleva, Yulia, Karetnikova, Victoria
Publicado no Drug Des Devel Ther (2015)

“..., resulted in a decrease in free fatty acid levels. The positive effect of low-dose atorvastatin (20 mg/day...”
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Effect of varying doses of tamoxifen on ovarian histopathology, serum VEGF, and endothelin 1 levels in ovarian hyperstimulation syndrome: an experimental study

Por Pala, Şehmus, Atilgan, Remzi, Ozkan¹, Zehra Sema, Kavak, Salih Burçin, Ilhan, Nevin, Akpolat, Nusret, Sapmaz, Ekrem
Publicado no Drug Des Devel Ther (2015)

“...). CONCLUSION: Tamoxifen 1 g and 3 g resulted in a dose-dependent increase in VEGF and endothelin 1 levels...”
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Analysis of pramipexole dose–response relationships in Parkinson’s disease

Por Wang, Ying, Sun, Sheng-Gang, Zhu, Sui-Qiang, Liu, Chun-Feng, Liu, Yi-Ming, Di, Qing, Shang, Hui-Fang, Ren, Yan, Xiang, Wei, Chen, Sheng-Di
Publicado no Drug Des Devel Ther (2016)

“... for Parkinson’s disease (PD). A critical dose level above which a better benefit-to-harm ratio exists has not been...”
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Time and dose relationships between schisandrin B- and schisandrae fructus oil-induced...

Por Zhang, Yi, Pan, Si-Yuan, Zhou, Shu-Feng, Wang, Xiao-Yan, Sun, Nan, Zhu, Pei-Li, Chu, Zhu-Sheng, Yu, Zhi-Ling, Ko, Kam-Ming
Publicado em 2014

“... fructus (SF). This study was conducted to compare the time- and dose-response between Sch B- and SF oil...”
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Clinical features of hypophosphatemic osteomalacia induced by long-term low-dose adefovir dipivoxil

Por Zhu, Sheng, Yang, Yu-Hui, Gao, Rong-Wei, Li, Ran, Zou, Yu-Zhen, Feng, Lei, Zhang, Bo
Publicado no Drug Des Devel Ther (2017)

“... alkaline phosphatase (ALP) level was 279.50 (137–548) U/L, which was significantly higher than the normal...”
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Dose comparison of conivaptan (Vaprisol(®)) in patients with euvolemic or hypervolemic hyponatremia – efficacy, safety, and pharmacokinetics

Por Palmer, Biff F, Rock, Amy D, Woodward, Emily J
Publicado no Drug Des Devel Ther (2016)

“... days, following an initial 20 mg loading dose. Efficacy was evaluated by the magnitude and extent...”
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Determining optimal dosing regimen of oral administration of dicloxacillin using Monte Carlo simulation

Por Yu, Wei, Ji, Jinru, Xiao, Tingting, Ying, Chaoqun, Fang, Jiaheng, Shen, Ping, Xiao, Yonghong
Publicado no Drug Des Devel Ther (2017)

“... level of toxicity. The objective of this study was to obtain optimal dosing regimen of oral...”
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When is high-dose intravenous iron repletion needed? Assessing new treatment options

Por Gozzard, David
Publicado em 2011

“... and its treatment. The literature indicates that high doses of iron are required, with levels of 1500 mg...”
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Identification of PPARγ ligands with One-dimensional Drug Profile Matching

Por Kovács, Diána, Simon, Zoltán, Hári, Péter, Málnási-Csizmadia, András, Hegedűs, Csaba, Drimba, László, Németh, József, Sári, Réka, Szilvássy, Zoltán, Peitl, Barna
Publicado em 2013

“... previously unknown therapeutic effects of generic drugs. Nitazoxanide can be the prototype chemical structure...”
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Pharmacokinetic interactions and tolerability of rosuvastatin and ezetimibe: an open-label, randomized, multiple-dose, crossover study in healthy male volunteers

Por Kim, Hyungsub, Choi, Hee Youn, Kim, Yo-Han, Bae, Kyun-Seop, Jung, Jina, Son, Hankil, Lim, Hyeong-Seok
Publicado no Drug Des Devel Ther (2018)

“... that effectively reduces low-density lipoprotein cholesterol levels. However, statin monotherapy does not always...”
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Effect of renal impairment on the pharmacokinetics of levomilnacipran following a single oral dose of levomilnacipran extended-release capsule in humans

Por Chen, Laishun, Greenberg, William M, Brand-Schieber, Elimor, Wangsa, Julie, Periclou, Antonia, Ghahramani, Parviz
Publicado no Drug Des Devel Ther (2015)

“... participant received one dose of levomilnacipran ER 40 mg. Blood and urine were assayed using liquid...”
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Multiple-dose pharmacokinetics and pharmacodynamics of evogliptin (DA-1229), a novel dipeptidyl peptidase IV inhibitor, in healthy volunteers

Por Gu, Namyi, Park, Min Kyu, Kim, Tae-Eun, Bahng, Mi Young, Lim, Kyoung Soo, Cho, Sang-Heon, Yoon, Seo Hyun, Cho, Joo-Youn, Jang, In-Jin, Yu, Kyung-Sang
Publicado em 2014

“..., placebo-controlled, multiple-dose, dose-escalation study was performed in a total of 30 subjects. Repeated...”
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Early achievement and maintenance of stable asthma control using initially higher-dose inhaled...

Por Cheng, Shih-Lung, Wang, Hao-Chien, Kuo, Sow-Hsong
Publicado em 2013

“.... In this study, we attempted to increase inhaled corticosteroid (ICS) doses initially in suboptimally controlled...”
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Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings

Por Kuca, Kamil, Karasova, Jana Zdarova, Soukup, Ondrej, Kassa, Jiri, Novotna, Eva, Sepsova, Vendula, Horova, Anna, Pejchal, Jaroslav, Hrabinova, Martina, Vodakova, Eva, Jun, Daniel, Nepovimova, Eugenie, Valis, Martin, Musilek, Kamil
Publicado no Drug Des Devel Ther (2018)

“... of currently used drugs led to research of novel potent molecules for prophylaxis of organophosphorus...”
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Dose-dependent effects of cisplatin on the severity of testicular injury in Sprague Dawley rats: reactive oxygen species and endoplasmic reticulum stress

Por Soni, Kiran Kumar, Kim, Hye Kyung, Choi, Bo Ram, Karna, Keshab Kumar, You, Jae Hyung, Cha, Jai Seong, Shin, Yu Seob, Lee, Sung Won, Kim, Chul Young, Park, Jong Kwan
Publicado no Drug Des Devel Ther (2016)

“... by increasing its dose over a constant time period. Sprague Dawley rats were divided into five treatment groups...”
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Determination of the starting dose in the first-in-human clinical trials with monoclonal antibodies...

Por Suh, Hoon Young, Peck, Carl C, Yu, Kyung-Sang, Lee, Howard
Publicado no Drug Des Devel Ther (2016)

“... biological effect level (MABEL)- or minimum effective dose (MED)-based approach was used more frequently...”
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PIVET rFSH dosing algorithms for individualized controlled ovarian stimulation enables optimized...

Por Yovich, John L, Alsbjerg, Birgit, Conceicao, Jason L, Hinchliffe, Peter M, Keane, Kevin N
Publicado no Drug Des Devel Ther (2016)

“...The first PIVET algorithm for individualized recombinant follicle stimulating hormone (rFSH) dosing...”
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Chronic obstructive pulmonary disease treated with inhaled medium- or high-dose corticosteroids: a...

Por Cheng, Shih-Lung, Su, Kang-Cheng, Wang, Hao-Chien, Perng, Diahn-Warng, Yang, Pan-Chyr
Publicado em 2014

“... disease (COPD) receiving inhaled corticosteroid (ICS) therapy have been documented. The aim of this study...”
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An open randomized active-controlled clinical trial with low-dose SKA cytokines versus DMARDs...

Por Martin-Martin, LS, Giovannangeli, F, Bizzi, E, Massafra, U, Ballanti, E, Cassol, M, Migliore, A
Publicado no Drug Des Devel Ther (2017)

“... patients were enrolled and randomized to continue disease-modifying antirheumatic drugs (DMARDs) therapy...”
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