Dose-dependent effects of cisplatin on the severity of testicular injury in Sprague Dawley rats: reactive oxygen species and endoplasmic reticulum stress

Cisplatin (CIS) is used in the treatment of cancer, but its nonspecific systemic actions lead to toxic effects on other parts of the body. This study investigated the severity of CIS toxicity by increasing its dose over a constant time period. Sprague Dawley rats were divided into five treatment gro...

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Bibliografiske detaljer
Udgivet i:Drug Des Devel Ther
Main Authors: Soni, Kiran Kumar, Kim, Hye Kyung, Choi, Bo Ram, Karna, Keshab Kumar, You, Jae Hyung, Cha, Jai Seong, Shin, Yu Seob, Lee, Sung Won, Kim, Chul Young, Park, Jong Kwan
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2016
Fag:
Hypothesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161341/
https://ncbi.nlm.nih.gov/pubmed/28003740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S120014
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