Resultados da pesquisa - (( j a pcsk9 can new ) OR (

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Cell-based, bioluminescent assay for monitoring the interaction between PCSK9 and the LDL receptor

Por Duellman, Sarah J., Machleidt, Thomas, Cali, James J., Vidugiriene, Jolanta
Publicado no J Lipid Res (2017)

“.... When the tagged PCSK9 binds the receptor, a bright luminescence signal is generated. The interaction...”
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PCSK9 inhibitors: A new era of lipid lowering therapy

Por Chaudhary, Rahul, Garg, Jalaj, Shah, Neeraj, Sumner, Andrew
Publicado no World J Cardiol (2017)

“... and Alirocumab. These agents target and inactivate proprotein convertase subtilsin-kexin type 9 (PCSK9), a...”
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Lipid Lowering Therapy and Circulating PCSK9 Concentration

Por Nozue, Tsuyoshi
Publicado no J Atheroscler Thromb (2017)

“.... In this review, the potential role of circulating PCSK9 as a new biomarker of lipid metabolism is described. Next...”
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PCSK9 signaling pathways and their potential importance in clinical practice

Por Wiciński, Michał, Żak, Jarosław, Malinowski, Bartosz, Popek, Gabriela, Grześk, Grzegorz
Publicado no EPMA J (2017)

“... on different levels. For example, silencing messenger RNA (mRNA of PCSK9) is a new alternative against...”
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AAV8-mediated overexpression of mPCSK9 in liver differs between male and female mice

Por Vozenilek, Aimee E., Blackburn, Cassidy M.R., Schilke, Robert M., Chandran, Sunitha, Castore, Reneau, Klein, Ronald L., Woolard, Matthew D.
Publicado no Atherosclerosis (2018)

“...-of-function mutation of mouse proprotein convertase subtilisin/kexin type 9 (AAV8- PCSK9) is a new model...”
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The Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Active Site and Cleavage Sequence Differentially Regulate Protein Secretion from Proteolysis

Por Chorba, John S., Shokat, Kevan M.
Publicado em 2014

“... of protein secretion independent of its role in proteolysis, revealing a new strategy for intracellular PCSK9...”
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All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo

Por Ibraheim, Raed, Song, Chun-Qing, Mir, Aamir, Amrani, Nadia, Xue, Wen, Sontheimer, Erik J.
Publicado no Genome Biol (2018)

“...-associated proteins (Cas) have recently opened a new avenue for gene therapy. Cas9 nuclease guided by a...”
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Recent advances in preventing stroke recurrence

Por Spence, J David
Publicado no F1000Res (2017)

“... for intracranial stenosis, and new therapies directed at proprotein convertase subtilisin–kexin type 9 (PCSK9...”
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Inhibition of PCSK9 Transcription by Berberine Involves Down-regulation of Hepatic HNF1α Protein...

Por Dong, Bin, Li, Hai, Singh, Amar Bahadur, Cao, Aiqin, Liu, Jingwen
Publicado no J Biol Chem (2015)

“... a new aspect of PCSK9 regulation by ubiquitin-induced proteasomal degradation of HNF1α....”
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Nature and Nurture in Atherosclerosis: The Roles of Acylcarnitine and Cell Membrane-Fatty Acid Intermediates

Por Blair, Harry C, Sepulveda, Jorge, Papachristou, Dionysios J.
Publicado no Vascul Pharmacol (2015)

“... are promising. These include preventative measures, and drugs including statins and the newer PCSK9 inhibitors...”
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Spotlight from the American Society for Preventive Cardiology on Key Features of the 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ ADA/AGS/APhA/ASPC/NLA/PCNA Guidelines on the Management of Blood Cholesterol

Por Wong, Nathan D., Amsterdam, Ezra A., Ballantyne, Christie, Khera, Amit, Nasir, Khurram, Toth, Peter P.
Publicado no Am J Cardiovasc Drugs (2020)

“... consideration for using a PCSK9 inhibitor. While the new guideline does have greater detail (and arguably...”
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Current and emerging treatments for hypercholesterolemia: A focus on statins and proprotein...

Por Trentman, Terrence L., Avey, Steven G., Ramakrishna, Harish
Publicado no J Anaesthesiol Clin Pharmacol (2016)

“... agents can significantly lower LDL-C levels. While PCSK9 inhibitors offer hope of effective therapy...”
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New Drugs for Treating Dyslipidemia: Beyond Statins

Por Ahn, Chang Ho, Choi, Sung Hee
Publicado no Diabetes Metab J (2015)

“... for the clinical practice. The pro-protein convertase subtilisin/kexintype 9 (PCSK9) inhibitor increases...”
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Emerging LDL Therapies: Using Human Genetics to Discover New Therapeutic Targets for Plasma Lipids

Por Cohen, Jonathan C.
Publicado em 2013

“... are Goldilocks alleles such as mutations in the gene for proprotein convertase subtilisin/kexin type 9 (PCSK9...”
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Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Vivo Genome Editing of Multiple Therapeutic Gene Targets

Por Conway, Anthony, Mendel, Matthew, Kim, Kenneth, McGovern, Kyle, Boyko, Alisa, Zhang, Lei, Miller, Jeffrey C., DeKelver, Russell C., Paschon, David E., Mui, Barbara L., Lin, Paulo J.C., Tam, Ying K., Barbosa, Chris, Redelmeier, Tom, Holmes, Michael C., Lee, Gary
Publicado no Mol Ther (2019)

“... formulated into LNP can enable >90% knockout of gene expression in mice by targeting the TTR or PCSK9 gene...”
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A felicidade do possível /

Por Ribeiro, Cláudio da Silva, Pereira, Carlos Américo Alves, Universidade Federal do Rio de Janeiro.
Publicado em 2000

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Half a Century Tales of Familial Hypercholesterolemia (FH) in Japan

Por Mabuchi, Hiroshi
Publicado no J Atheroscler Thromb (2017)

“... statin therapy. Clinical results using anti-PCSK9 monoclonal antibodies will emerge in a few years...”
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SUN-070 Asymptomatic Patients with Homozygous Familial Hypercholesterolemia: A Challenge

Por Lam, Cesar, Cruz, Ivette, Mehta, Roopa, Espinola, Nilda, Tusie-Luna, Maria Teresa, Carvajal-Juarez, Isabel, Flores-García, Alondra, Martagón, Alexandro, Rosales, Sandra, Gomez-Perez, Francisco, Lopez, Rafaelina, Gonzalez, Gustavo, Aguilar Salinas, Carlos
Publicado no J Endocr Soc (2019)

“... with active tissue calcifications. The patient is currently receiving PCSK-9 inhibitor bi-monthly. Conclusion...”
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A questão da longevidade saudável após processos de reestruturação : o caso RFFSA ALL /

Por Tiecher, Luiz Eduardo Gonçalves., Lemgruber, Eduardo Facó., Universidade Federal do Rio de Janeiro.
Publicado em 2009

“... países. As políticas neo-liberais do período incentivaram a redução da participação dos governos em...”
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Is There an Ideal Low-Density Lipoprotein Cholesterol Level? Confusion regarding Lipid Guidelines, Low-Density Lipoprotein Cholesterol Targets, and Medical Management

Por Whayne, Thomas F.
Publicado no Int J Angiol (2016)

“... desired LDL-C level while on a high-dose statin. These new PCSK9 inhibitors necessitate a determination...”
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