Inhibition of PCSK9 Transcription by Berberine Involves Down-regulation of Hepatic HNF1α Protein Expression through the Ubiquitin-Proteasome Degradation Pathway

Our previous in vitro studies have identified hepatocyte nuclear factor 1α (HNF1α) as an obligated trans-activator for PCSK9 gene expression and demonstrated its functional involvement in the suppression of PCSK9 expression by berberine (BBR), a natural cholesterol-lowering compound. In this study,...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Dong, Bin, Li, Hai, Singh, Amar Bahadur, Cao, Aiqin, Liu, Jingwen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Lipids
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326815/
https://ncbi.nlm.nih.gov/pubmed/25540198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.597229
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