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Janus kinase activation by cytokine oncostatin M decreases PCSK9 expression in liver cells
PCSK9 degrades LDL receptor (LDLR) in liver and thereby influences the circulating level of LDL cholesterol. Hence, mechanisms inhibiting PCSK9 expression have potential for cholesterol-lowering intervention. Previously, we demonstrated that oncostatin M (OM) activates LDLR gene transcription, resul...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3035688/ https://ncbi.nlm.nih.gov/pubmed/21196532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M010603 |
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