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21

Teplizumab Preserves C-Peptide in Recent-Onset Type 1 Diabetes: Two-Year Results From the Randomized, Placebo-Controlled Protégé Trial

Teplizumab Preserves C-Peptide in Recent-Onset Type 1 Diabetes: Two-Year Results From the Randomized, Placebo-Controlled Protégé Trial

Por Hagopian, William, Ferry, Robert J., Sherry, Nicole, Carlin, David, Bonvini, Ezio, Johnson, Syd, Stein, Kathryn E., Koenig, Scott, Daifotis, Anastasia G., Herold, Kevan C., Ludvigsson, Johnny
Publicado em 2013

“..., in new-onset type 1 diabetes. We sought to determine efficacy and safety of teplizumab immunotherapy at 2...”
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22

Bone Loss in Diabetes: Use of Antidiabetic Thiazolidinediones and Secondary Osteoporosis

Bone Loss in Diabetes: Use of Antidiabetic Thiazolidinediones and Secondary Osteoporosis

Por Lecka-Czernik, Beata
Publicado em 2010

“... of fractures. One class of antidiabetic drugs, thiazolidinediones (TZDs), causes bone loss and further...”
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23

The weight lowering effect of sibutramine and its impact on serum lipids in cardiovascular high risk patients with and without type 2 diabetes mellitus - an analysis from the SCOUT lead-in period

The weight lowering effect of sibutramine and its impact on serum lipids in cardiovascular high risk patients with and without type 2 diabetes mellitus - an analysis from the SCOUT lead-in period

Por Weeke, Peter, Andersson, Charlotte, Fosbøl, Emil L, Brendorp, Bente, Køber, Lars, Sharma, Arya M, Finer, Nick, James, Philip T, Caterson, Ian D, Rode, Richard A, Torp-Pedersen, Christian
Publicado em 2010

“... associated with the risk of developing cardiovascular disease (CVD). We examined whether blood lipid changes...”
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24

Animal model of mucosally transmitted human immunodeficiency virus type 1 disease: intravaginal and oral deposition of simian/human immunodeficiency virus in macaques results in systemic infection, elimination of CD4+ T cells, and AIDS.

Animal model of mucosally transmitted human immunodeficiency virus type 1 disease: intravaginal...

Por Joag, S V, Adany, I, Li, Z, Foresman, L, Pinson, D M, Wang, C, Stephens, E B, Raghavan, R, Narayan, O
Publicado em 1997

“... of human immunodeficiency virus type 1 (HIV-1) on a background of simian immunodeficiency virus (SIV). We...”
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25

Diazepam-induced loss of inhibitory synapses mediated by PLCδ/ Ca(2+)/calcineurin signalling downstream of GABAA receptors

Diazepam-induced loss of inhibitory synapses mediated by PLCδ/ Ca(2+)/calcineurin signalling downstream of GABAA receptors

Por Nicholson, Martin W., Sweeney, Aaron, Pekle, Eva, Alam, Sabina, Ali, Afia B., Duchen, Michael, Jovanovic, Jasmina N.
Publicado no Mol Psychiatry (2018)

“...Benzodiazepines facilitate the inhibitory actions of GABA by binding to γ-aminobutyric acid type A...”
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26

Gemcitabine resistant pancreatic cancer cell lines acquire an invasive phenotype with collateral hypersensitivity to histone deacetylase inhibitors

Gemcitabine resistant pancreatic cancer cell lines acquire an invasive phenotype with collateral hypersensitivity to histone deacetylase inhibitors

Por Samulitis, Betty K, Pond, Kelvin W, Pond, Erika, Cress, Anne E, Patel, Hitendra, Wisner, Lee, Patel, Charmi, Dorr, Robert T, Landowski, Terry H
Publicado no Cancer Biol Ther (2014)

“... pancreatic cancer, we developed a series of gemcitabine resistant (GR) cell lines. Initial drug exposure...”
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27

Evaluation of the cytotoxicity of the Bithionol - cisplatin combination in a panel of human ovarian cancer cell lines

Evaluation of the cytotoxicity of the Bithionol - cisplatin combination in a panel of human ovarian cancer cell lines

Por Ayyagari, Vijayalakshmi N., Hsieh, Tsung-han Jeff, Diaz-Sylvester, Paula L., Brard, Laurent
Publicado no BMC Cancer (2017)

“... and reduce drug-related toxicities in ovarian cancer treatments. In this in vitro study, we evaluated...”
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28

Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy

Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy

Por Rocha-Ferreira, Eridan, Poupon, Laura, Zelco, Aura, Leverin, Anna-Lena, Nair, Syam, Jonsdotter, Andrea, Carlsson, Ylva, Thornton, Claire, Hagberg, Henrik, Rahim, Ahad A
Publicado no Brain (2018)

“... and treatment with therapeutic hypothermia, over 50% of cooled infants are not protected and still develop...”
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29

Repurposing a novel parathyroid hormone analogue to treat hypoparathyroidism

Repurposing a novel parathyroid hormone analogue to treat hypoparathyroidism

Por Krishnan, Venkatesh, Ma, Yanfei L, Chen, Catherine Z, Thorne, Natasha, Bullock, Heather, Tawa, Gregory, Javella‐Cauley, Christy, Chu, Shaoyou, Li, Weiming, Kohn, Wayne, Adrian, Mary D, Benson, Charles, Liu, Lifei, Sato, Masahiko, Zheng, Wei, Pilon, Andre M, Yang, N. Nora, Bryant, Henry U
Publicado no Br J Pharmacol (2017)

“... to treatment with wild‐type PTH. CONCLUSIONS AND IMPLICATIONS: We summarize the repositioning of a therapeutic...”
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30

Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737–Mediated Cell Death in Malignant Human Glioma Cell Lines

Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737–Mediated Cell Death in Malignant Human Glioma Cell Lines

Por Jane, Esther P., Premkumar, Daniel R., Cavaleri, Jonathon M., Sutera, Philip A., Rajasekar, Thatchana, Pollack, Ian F.
Publicado no J Pharmacol Exp Ther (2016)

“... the need to develop novel treatment strategies. Because glioma cells commonly exhibit genomic alterations...”
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31

Tinnitus Onset Rates from Chemotherapeutic Agents and Ototoxic Antibiotics: Results of a Large Prospective Study

Tinnitus Onset Rates from Chemotherapeutic Agents and Ototoxic Antibiotics: Results of a Large Prospective Study

Por Dille, Marilyn F., Konrad-Martin, Dawn, Gallun, Frederick, Helt, Wendy J., Gordon, Jane S., Reavis, Kelly M., Bratt, Gene W., Fausti, Stephen A.
Publicado no J Am Acad Audiol (2010)

“... by the type of medication taken, age, presence of preexisting hearing loss, days on drug, and cumulative dose...”
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32

A novel curcumin derivative for the treatment of diabetic neuropathy

A novel curcumin derivative for the treatment of diabetic neuropathy

Por Daugherty, Daniel J., Marquez, Alexandra, Calcutt, Nigel A., Schubert, David
Publicado no Neuropharmacology (2017)

“... neurogenic and neuroprotective drug candidate initially developed for the treatment of neurodegenerative...”
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33

Intrathecal 2-Hydroxypropyl-Beta-Cyclodextrin in a Single Patient with Niemann-Pick C1

Intrathecal 2-Hydroxypropyl-Beta-Cyclodextrin in a Single Patient with Niemann-Pick C1

Por Maarup, Timothy J., Chen, Agnes H., Porter, Forbes D., Farhat, Nicole Y., Ory, Daniel S., Sidhu, Rohini, Jiang, Xuntian, Dickson, Patricia I.
Publicado no Mol Genet Metab (2015)

“... and Drug Administration approved treatments for NPC1. We undertook a study evaluating the safety, efficacy...”
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34

Neuroprotective Effect of Ramipril Is Mediated by AT2 in a Mouse MODEL of Paclitaxel-Induced Peripheral Neuropathy

Neuroprotective Effect of Ramipril Is Mediated by AT2 in a Mouse MODEL of Paclitaxel-Induced Peripheral Neuropathy

Por Hichem Bouchenaki, Amandine Bernard, Flavien Bessaguet, Simon Frachet, Laurence Richard, Franck Sturtz, Laurent Magy, Sylvie Bourthoumieu, Claire Demiot, Aurore Danigo
Publicado em 2022-04-01

“... quality of life, leading to decreased doses or even to cessation of anticancer therapy. Previous studies...”
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35

Lack of weight gain after angiotensin AT(1) receptor blockade in diet-induced obesity is partly mediated by an angiotensin-(1–7)/ Mas-dependent pathway

Lack of weight gain after angiotensin AT(1) receptor blockade in diet-induced obesity is partly mediated by an angiotensin-(1–7)/ Mas-dependent pathway

Por Schuchard, Johanna, Winkler, Martina, Stölting, Ines, Schuster, Franziska, Vogt, Florian M, Barkhausen, Jörg, Thorns, Christoph, Santos, Robson A, Bader, Michael, Raasch, Walter
Publicado no Br J Pharmacol (2015)

“... of transgenically overexpressed angiotensin-(1-7) in rats. We secondly examined whether weight loss due...”
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36

$Lenvatinib and other tyrosine kinase inhibitors for the treatment of radioiodine refractory, advanced, and progressive thyroid cancer$

Lenvatinib and other tyrosine kinase inhibitors for the treatment of radioiodine refractory, advanced, and progressive thyroid cancer

Por Lorusso, Loredana, Pieruzzi, Letizia, Biagini, Agnese, Sabini, Elena, Valerio, Laura, Giani, Carlotta, Passannanti, Paolo, Pontillo-Contillo, Benedetta, Battaglia, Valentina, Mazzeo, Salvatore, Molinaro, Eleonora, Elisei, Rossella
Publicado no Onco Targets Ther (2016)

“... and the protooncogene c-KIT, this drug can also be used to control tumor cell proliferation. The maximum tolerated dose...”
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37

Efficacy of topical tenofovir against transmission of a tenofovir-resistant SHIV in macaques

Efficacy of topical tenofovir against transmission of a tenofovir-resistant SHIV in macaques

Por Dobard, Charles W, Sharma, Sunita, Cong, Mian-er, West, Rolieria, Makarova, Natalia, Holder, Angela, Pau, Chou-Pong, Hanson, Debra L., Novembre, Francis J, Garcia-Lerma, Jose Gerardo, Heneine, Walid
Publicado no Retrovirology (2015)

“... evaluated for HIV prevention. We previously demonstrated that TFV delivered vaginally by gel protected...”
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38

Knowledge on leprosy and its management among primary healthcare providers in two districts of Bangladesh

Knowledge on leprosy and its management among primary healthcare providers in two districts of Bangladesh

Por Humayun Kabir, Shahed Hossain
Publicado em 2019-11-01

“... treatment, and drug use for paucibacillary (PB) and multibacillary (MB) leprosy cases. Methods We conducted...”
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39

Albumin-coated nanocrystals for carrier-free delivery of paclitaxel

Albumin-coated nanocrystals for carrier-free delivery of paclitaxel

Por Park, Joonyoung, Sun, Bo, Yeo, Yoon
Publicado no J Control Release (2016)

“... these challenges, we developed an albumin-coated nanocrystal (NC) formulation of paclitaxel (PTX) with 90% drug...”
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40

Atovaquone ameliorate gastrointestinal Toxoplasmosis complications in a pregnancy model

Atovaquone ameliorate gastrointestinal Toxoplasmosis complications in a pregnancy model

Por Oz, Helieh S., Tobin, Thomas
Publicado em 2012

“... and effective therapy against chronic or congenital Toxopalsmosis. Atovaquone is a drug of choice...”
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