Diazepam-induced loss of inhibitory synapses mediated by PLCδ/ Ca(2+)/calcineurin signalling downstream of GABAA receptors

Benzodiazepines facilitate the inhibitory actions of GABA by binding to γ-aminobutyric acid type A receptors (GABA(A)Rs), GABA-gated chloride/bicarbonate channels, which are the key mediators of transmission at inhibitory synapses in the brain. This activity underpins potent anxiolytic, anticonvulsa...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Psychiatry
Main Authors: Nicholson, Martin W., Sweeney, Aaron, Pekle, Eva, Alam, Sabina, Ali, Afia B., Duchen, Michael, Jovanovic, Jasmina N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232101/
https://ncbi.nlm.nih.gov/pubmed/29904150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-018-0100-y
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados