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Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737–Mediated Cell Death in Malignant Human Glioma Cell Lines

The prognosis for malignant glioma, the most common brain tumor, is still poor, underscoring the need to develop novel treatment strategies. Because glioma cells commonly exhibit genomic alterations involving genes that regulate cell-cycle control, there is a strong rationale for examining the poten...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Pharmacol Exp Ther
मुख्य लेखकों: Jane, Esther P., Premkumar, Daniel R., Cavaleri, Jonathon M., Sutera, Philip A., Rajasekar, Thatchana, Pollack, Ian F.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The American Society for Pharmacology and Experimental Therapeutics 2016
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047232/
https://ncbi.nlm.nih.gov/pubmed/26585571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.230052
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