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Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737–Mediated Cell Death in Malignant Human Glioma Cell Lines

The prognosis for malignant glioma, the most common brain tumor, is still poor, underscoring the need to develop novel treatment strategies. Because glioma cells commonly exhibit genomic alterations involving genes that regulate cell-cycle control, there is a strong rationale for examining the poten...

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Pubblicato in:J Pharmacol Exp Ther
Autori principali: Jane, Esther P., Premkumar, Daniel R., Cavaleri, Jonathon M., Sutera, Philip A., Rajasekar, Thatchana, Pollack, Ian F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047232/
https://ncbi.nlm.nih.gov/pubmed/26585571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.230052
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