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Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737–Mediated Cell Death in Malignant Human Glioma Cell Lines

The prognosis for malignant glioma, the most common brain tumor, is still poor, underscoring the need to develop novel treatment strategies. Because glioma cells commonly exhibit genomic alterations involving genes that regulate cell-cycle control, there is a strong rationale for examining the poten...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Jane, Esther P., Premkumar, Daniel R., Cavaleri, Jonathon M., Sutera, Philip A., Rajasekar, Thatchana, Pollack, Ian F.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047232/
https://ncbi.nlm.nih.gov/pubmed/26585571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.230052
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