Resultados da pesquisa - (( a nagy chirp can netw ) OR ((( 5 soil company can new ) OR ( a small compound a now ))))

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1

Novel patient-derived xenograft mouse model for pancreatic acinar cell carcinoma demonstrates single agent activity of oxaliplatin

Novel patient-derived xenograft mouse model for pancreatic acinar cell carcinoma demonstrates single agent activity of oxaliplatin

Por Hall, Jason C., Marlow, Laura A., Mathias, Adam C., Dawson, Louis K., Durham, William F., Meshaw, Kenneth A., Mullin, Robert J., Synnott, Aidan J., Small, Daniel L., Krishna, Murli, von Hoff, Daniel, Schüler, Julia, Hart, Steven N., Couch, Fergus J., Colon-Otero, Gerardo, Copland, John A.
Publicado no J Transl Med (2016)

“... cells developed from their liver metastasis. We now report the characterization of a patient derived...”
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Artigo

2

Specific estrogen sulfotransferase (SULT1E1) substrates and molecular imaging probe candidates

Specific estrogen sulfotransferase (SULT1E1) substrates and molecular imaging probe candidates

Por Cole, Graham B., Keum, Gyochang, Liu, Jie, Small, Gary W., Satyamurthy, Nagichettiar, Kepe, Vladimir, Barrio, Jorge R.
Publicado em 2010

“...) to produce molecular imaging probes for this enzyme. SULT1E1 is a key enzyme in estrogen homeostasis, playing...”
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Artigo

3

Small molecule Photoregulin3 prevents retinal degeneration in the Rho(P23H) mouse model of retinitis pigmentosa

Small molecule Photoregulin3 prevents retinal degeneration in the Rho(P23H) mouse model of retinitis pigmentosa

Por Nakamura, Paul A, Shimchuk, Andy A, Tang, Shibing, Wang, Zhizhi, DeGolier, Kole, Ding, Sheng, Reh, Thomas A
Publicado no eLife (2017)

“..., in vivo analyses were not possible with PR1. We now report a structurally unrelated compound, Photoregulin...”
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4

The spasmogenic effects of vanadate in human isolated bronchus

The spasmogenic effects of vanadate in human isolated bronchus

Por Cortijo, Julio, Villagrasa, Victoria, Martí-Cabrera, Miguel, Villar, Vicente, Moreau, Joelle, Advenier, Charles, Morcillo, Esteban J, Small, Roger C
Publicado em 1997

“...1. Inhalation of vanadium compounds, particularly vanadate, is a cause of occupational bronchial...”
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Artigo

5

MET As a Possible Target for Non–Small-Cell Lung Cancer

MET As a Possible Target for Non–Small-Cell Lung Cancer

Por Sadiq, Ahad A., Salgia, Ravi
Publicado em 2013

“...Lung cancer is a heterogeneous group of disorders that is now being subdivided into molecular...”
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6

Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes.

Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes.

Por Hershko, A, Rose, I A
Publicado em 1987

“... hydrolase, has previously been reported. We now examine the action of this compound on the Ub-mediated...”
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7

Altered plasmodial surface anion channel activity and in vitro resistance to permeating antimalarial compounds

Altered plasmodial surface anion channel activity and in vitro resistance to permeating antimalarial compounds

Por Lisk, Godfrey, Pain, Margaret, Sellers, Morgan, Gurnev, Philip A., Pillai, Ajay D., Bezrukov, Sergey M., Desai, Sanjay A.
Publicado em 2010

“.... These changes may be mediated by an unusual small conductance ion channel known as the plasmodial surface anion...”
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8

Small-molecule inhibitors of protein-protein interactions: progressing towards the reality

Small-molecule inhibitors of protein-protein interactions: progressing towards the reality

Por Arkin, Michelle R., Tang, Yinyan, Wells, James A.
Publicado em 2014

“... (PPI) and how to target them with small-molecule therapeutics. In 2004, we reviewed some early...”
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9

Identification of Novel Small-Molecule Agonists for Human Formyl Peptide Receptors and Pharmacophore Models of Their Recognition

Identification of Novel Small-Molecule Agonists for Human Formyl Peptide Receptors and Pharmacophore Models of Their Recognition

Por Kirpotina, Liliya N., Khlebnikov, Andrei I., Schepetkin, Igor A., Ye, Richard D., Rabiet, Marie-Josèphe, Jutila, Mark A., Quinn, Mark T.
Publicado em 2010

“...N-formyl peptide receptor (FPR1) and N-formyl peptide receptor-like 1 (FPRL1, now known as FPR2...”
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10

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

Por Sigrid A. Langhans
Publicado em 2018-01-01

“...Drug development is a lengthy and costly process that proceeds through several stages from target...”
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Artigo

11

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

Por Langhans, Sigrid A.
Publicado no Front Pharmacol (2018)

“...Drug development is a lengthy and costly process that proceeds through several stages from target...”
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12

The Zymark BenchMate™. A compact, fully-automated solution-phase reaction work-up facility for multiple parallel synthesis

The Zymark BenchMate™. A compact, fully-automated solution-phase reaction work-up facility for multiple parallel synthesis

Por Hamlin, Gordon A.
Publicado em 2000

“... of large numbers of small-scale reactions is both time-consuming and tedious, and is a rate limiting step...”
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13

Introducing iron isomaltoside 1000 (Monofer®)—development rationale and clinical experience

Introducing iron isomaltoside 1000 (Monofer®)—development rationale and clinical experience

Por Kalra, Philip A.
Publicado no NDT Plus (2011)

“... in these patients and that IV supplementation is a more effective treatment. Until now, use of available parenteral...”
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14

High content screen for identifying small-molecule LC3B-localization modulators in a renal cancer cell line

High content screen for identifying small-molecule LC3B-localization modulators in a renal cancer cell line

Por Kolla, Likhitha, Heo, David S., Rosenberg, Daniel P., Barlow, Sara A., Maximova, Anna A., Cassio, Emily E., Buchser, William J.
Publicado no Sci Data (2018)

“... in vitro. Here, we describe a high content screen from which we identified small chemical compounds...”
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15

Modern magnetic resonance part 1: applications in chemistry, biological and marine sciences /

Modern magnetic resonance part 1: applications in chemistry, biological and marine sciences /

Por Webb, Graham A.
Publicado em 2006

“...Modern Magnetic Resonance provides a unique and comprehensive resource on up-to-date uses...”
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Livro

16

Progress in Biological Therapies for Adult-Onset Still’s Disease

Progress in Biological Therapies for Adult-Onset Still’s Disease

Por Galozzi P, Bindoli S, Doria A, Sfriso P
Publicado em 2022-04-01

Assuntos: “...small molecules...”
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Artigo

17

Discovery of Novel Cell Wall-Active Compounds Using P(ywaC), a Sensitive Reporter of Cell Wall Stress, in the Model Gram-Positive Bacterium Bacillus subtilis

Discovery of Novel Cell Wall-Active Compounds Using P(ywaC), a Sensitive Reporter of Cell Wall Stress, in the Model Gram-Positive Bacterium Bacillus subtilis

Por Czarny, T. L., Perri, A. L., French, S., Brown, E. D.
Publicado em 2014

“... of many antibacterial treatments and now poses a significant threat to public health. One of the earliest...”
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18

Synergy of Small Molecular Inhibitors of Hepatitis C Virus Replication Directed at Multiple Viral Targets

Synergy of Small Molecular Inhibitors of Hepatitis C Virus Replication Directed at Multiple Viral Targets

Por Wyles, David L., Kaihara, Kelly A., Vaida, Florin, Schooley, Robert T.
Publicado em 2007

“... therapeutic options. A number of novel, small molecular inhibitors of HCV replication are now entering early...”
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19

Efficacy of drug prophylaxis.

Efficacy of drug prophylaxis.

Por Phillips-Howard, P A
Publicado em 1989

“... drugs, malaria preventive guidelines switched from chloroquine to the newer compound antimalarial drugs...”
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20

Distribution and chemotaxonomic significance of phenolic compounds in Spermacoce verticillata (L.) G. Mey

Distribution and chemotaxonomic significance of phenolic compounds in Spermacoce verticillata (L.) G. Mey

Por Iasmim C. Lima, Rosane Nora, Mário G. de Carvalho, Douglas S.A. Chaves
Publicado no Journal of Pharmacy & Pharmacognosy Research (2014)

“... species, small, upright perennial, and broadly distributed throughout Brazil. Until now, few chemical...”
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