Design, development, drug-likeness, and molecular docking studies of novel piperidin-4-imine derivatives as antitubercular agents

Por Revathi, Rajappan, Venkatesha Perumal, Ramachandran, Pai, Karkala Sreedhara Ranganath, Arunkumar, Govindakarnavar, Sriram, Dharmarajan, Kini, Suvarna Ganesh
Publicado no Drug Des Devel Ther (2015)

Clinicopathological significance and potential drug targeting of CDH1 in lung cancer: a meta-analysis and literature review

Por Yu, Qiaowen, Guo, Qisen, Chen, Liangan, Liu, Shuwei
Publicado no Drug Des Devel Ther (2015)

OpenVigil FDA – Inspection of U.S. American Adverse Drug Events Pharmacovigilance Data and Novel Clinical Applications

Por Böhm, Ruwen, von Hehn, Leocadie, Herdegen, Thomas, Klein, Hans-Joachim, Bruhn, Oliver, Petri, Holger, Höcker, Jan
Publicado no PLoS One (2016)

Tumor Growth Rate (TGR) is an early indicator of anti-tumor drug activity in phase I clinical trials

Por Ferté, Charles, Fernandez, Marianna, Hollebecque, Antoine, Koscielny, Serge, Levy, Antonin, Massard, Christophe, Balheda, Rastislav, Bot, Brian, Gomez-Roca, Carlos, Dromain, Clarisse, Ammari, Samy, Soria, Jean-Charles
Publicado em 2013

Chronic oral administration of minocycline to sheep with ovine CLN6 neuronal ceroid lipofuscinosis maintains pharmacological concentrations in the brain but does not suppress neuroinflammation or disease...

Por Kay, Graham W, Palmer, David N
Publicado em 2013

Anesthetic drug midazolam inhibits cardiac human ether-à-go-go-related gene channels: mode of action

Por Vonderlin, Nadine, Fischer, Fathima, Zitron, Edgar, Seyler, Claudia, Scherer, Daniel, Thomas, Dierk, Katus, Hugo A, Scholz, Eberhard P
Publicado no Drug Des Devel Ther (2015)

AN EXPERIMENTAL ANALYSIS OF THE CURATIVE ACTION OF PENICILLIN IN ACUTE BACTERIAL INFECTIONS : III. THE EFFFECT OF SUPPURATION UPON THE ANTIBACTERIAL ACTION OF THE DRUG

Por Smith, Mary Ruth, Wood, W. Barry
Publicado em 1956

Pharmacogenomics of anesthetic drugs in transgenic LQT1 and LQT2 rabbits reveal genotype-specific differential effects on cardiac repolarization

Por Odening, Katja E., Hyder, Omar, Chaves, Leonard, Schofield, Lorraine, Brunner, Michael, Kirk, Malcolm, Zehender, Manfred, Peng, Xuwen, Koren, Gideon
Publicado em 2008

Physiologically based and population PK modeling in optimizing drug development: A predict–learn–confirm analysis

Por Suri, A, Chapel, S, Lu, C, Venkatakrishnan, K
Publicado no Clin Pharmacol Ther (2015)

A New Screen for Tuberculosis Drug Candidates Utilizing a Luciferase-Expressing Recombinant Mycobacterium bovis Bacillus Calmette-Guéren

Por Ozeki, Yuriko, Igarashi, Masayuki, Doe, Matsumi, Tamaru, Aki, Kinoshita, Naoko, Ogura, Yoshitoshi, Iwamoto, Tomotada, Sawa, Ryuichi, Umekita, Maya, Enany, Shymaa, Nishiuchi, Yukiko, Osada-Oka, Mayuko, Hayashi, Tetsuya, Niki, Mamiko, Tateishi, Yoshitaka, Hatano, Masaki, Matsumoto, Sohkichi
Publicado no PLoS One (2015)

Risk of Neoplasia in Pediatric Patients Receiving Growth Hormone Therapy—A Report From the Pediatric Endocrine Society Drug and Therapeutics Committee

Por Raman, Sripriya, Grimberg, Adda, Waguespack, Steven G., Miller, Bradley S., Sklar, Charles A., Meacham, Lillian R., Patterson, Briana C.
Publicado no J Clin Endocrinol Metab (2015)

Human pluripotent stem cell-derived cardiomyocytes for heart regeneration, drug discovery...

Por Chow, Maggie Zi, Boheler, Kenneth R, Li, Ronald A
Publicado em 2013

Efflux pumps of Gram-negative bacteria: what they do, how they do it, with what and how to deal with them

Por Amaral, Leonard, Martins, Ana, Spengler, Gabriella, Molnar, Joseph
Publicado em 2014

A meta-analysis for C-X-C chemokine receptor type 4 as a prognostic marker and potential drug target in hepatocellular carcinoma

Por Hu, Fei, Miao, Lin, Zhao, Yu, Xiao, Yuan-Yuan, Xu, Qing
Publicado no Drug Des Devel Ther (2015)

A network flow approach to predict drug targets from microarray data, disease genes and interactome network - case study on prostate cancer

Por Yeh, Shih-Heng, Yeh, Hsiang-Yuan, Soo, Von-Wun
Publicado em 2012

Pediatric tuberculous meningitis: model-based approach to determining optimal doses of the anti-tuberculosis drugs rifampin and levofloxacin for children

Por Savic, Radojka M., Ruslami, Rovina, Hibma, Jennifer E., Hesseling, Anneke, Ramachandran, Geetha, Ganiem, A. Rizal, Swaminathan, Soumya, McIlleron, Helen, Gupta, Amita, Thakur, Kiran, van Crevel, Reinout, Aarnoutse, Rob, Dooley, Kelly E.
Publicado no Clin Pharmacol Ther (2015)

Visual detection of glial cell line-derived neurotrophic factor based on a molecular translator and isothermal strand-displacement polymerization reaction

Por Zhang, Li-Yong, Xing, Tao, Du, Li-Xin, Li, Qing-Min, Liu, Wei-Dong, Wang, Ji-Yue, Cai, Jing
Publicado no Drug Des Devel Ther (2015)

Paying for the Orphan Drug System: break or bend? Is it time for a new evaluation system for payers in Europe to take account of new rare disease treatments?

Por Hughes-Wilson, Wills, Palma, Ana, Schuurman, Ad, Simoens, Steven
Publicado em 2012

N-(3-hydroxymethyl-β-carboline-1-yl-ethyl- 2-yl)-l-Phe: development toward a nanoscaled antitumor...

Por Wu, Jianhui, Zhao, Ming, Wang, Yuji, Wang, Yaonan, Zhu, Haimei, Zhao, Shurui, Gui, Lin, Zhang, Xiaoyi, Peng, Shiqi
Publicado no Drug Des Devel Ther (2017)

Development of novel HER2 inhibitors against gastric cancer derived from flavonoid source...

Por Babu, Tirumalasetty Muni Chandra, Rammohan, Aluru, Baki, Vijaya Bhaskar, Devi, Savita, Gunasekar, Duvvuru, Rajendra, Wudayagiri
Publicado no Drug Des Devel Ther (2016)