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Chronic oral administration of minocycline to sheep with ovine CLN6 neuronal ceroid lipofuscinosis maintains pharmacological concentrations in the brain but does not suppress neuroinflammation or disease progression
BACKGROUND: The neuronal ceroid lipofuscinoses (NCLs; or Batten disease) are fatal inherited human neurodegenerative diseases affecting an estimated 1:12,500 live births worldwide. They are caused by mutations in at least 11 different genes. Currently, there are no effective treatments. Progress int...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3733893/ https://ncbi.nlm.nih.gov/pubmed/23899308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-10-97 |
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