Chronic oral administration of minocycline to sheep with ovine CLN6 neuronal ceroid lipofuscinosis maintains pharmacological concentrations in the brain but does not suppress neuroinflammation or disease progression

BACKGROUND: The neuronal ceroid lipofuscinoses (NCLs; or Batten disease) are fatal inherited human neurodegenerative diseases affecting an estimated 1:12,500 live births worldwide. They are caused by mutations in at least 11 different genes. Currently, there are no effective treatments. Progress int...

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Main Authors: Kay, Graham W, Palmer, David N
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733893/
https://ncbi.nlm.nih.gov/pubmed/23899308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-10-97
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