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Establishment and maintenance of an R6/1 transgenic mouse colony and validation of its progressive neurological phenotype to study Huntington’s disease

Huntington’s disease (HD) is a hereditary neurodegenerative disorder of the central nervous system that mainly affects the basal ganglia and has no cure. The mutation is located at an abnormal expansion of the CAG triplet in the Huntingtin gene. Humans show psychiatric, behavioural and motor disorde...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Veterinaria México
Main Authors: Lucia García-Lara, Adriana Morales-Martínez, Quetzalli D. Angeles-López, Hilda Pedraza-Espitia, Iván Pérez-Neri, Cesar A. Rodríguez-Balderas, Francisca Pérez-Severiano
Format: Artigo
Jezik:Inglês
Izdano: Universidad Nacional Autónoma de México 2018
Teme:
R6
Online dostop:https://www.redalyc.org/articulo.oa?id=42371695003
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