Pharmacokinetics and pharmacodynamics of the new oral anticoagulants

Dabigatran is the first available oral direct thrombin inhibitor anticoagulant. Absorption of the prodrug, dabigatran etexilate and its conversion to dabigatran is rapid (peak plasma concentrations are reached 4-6 h following surgery, and a further 2 h later). Its oral bioavailability is low, but sh...

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Detalhes bibliográficos
Publicado no:Farmacia Hospitalaria
Main Authors: Juan Pablo Ordovás Baines, Eduardo Climent Grana, Alejandro Jover Botella, Isabel Valero García
Formato: Artigo
Idioma:Inglês
Publicado em: Sociedad Española de Farmacia Hospitalaria 2009
Assuntos:
Medicina
Anticoagulants
Pharmacokinetics
Pharmacodynamics
Direct thrombin inhibitors
Direct factor Xa inhibitors
Acesso em linha:https://www.redalyc.org/articulo.oa?id=365961790007
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