Effect of itraconazole on the pharmacokinetics and pharmacodynamics of a single oral dose of brotizolam

AIMS: To assess the effect of itraconazole, a potent inhibitor of cytochrome P450 (CYP)3A4, on the single oral dose pharmacokinetics and pharmacodynamics of brotizolam. METHODS: In this randomized, double-blind, cross-over trial 10 healthy male subjects received either itraconazole 200 mg or matched...

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Detaylı Bibliyografya
Asıl Yazarlar: Osanai, T, Ohkubo, T, Yasui, N, Kondo, T, Kaneko, S
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 2004
Konular:
Pharmacokinetics/Pharmacodynamics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884630/
https://ncbi.nlm.nih.gov/pubmed/15521894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.02208.x
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