The pentose phosphate pathway in Trypanosoma cruzi: a potential target for the chemotherapy of Chagas disease

Trypanosoma cruzi is highly sensitive to oxidative stress caused by reactive oxygen species. Trypanothione, theparasite’s major protection against oxidative stress, is kept reduced by trypanothione reductase, using NADPH; themajor source of the reduced coenzyme seems to be the pentose phosphate path...

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Bibliografiske detaljer
Udgivet i:Anais da Academia Brasileira de Ciências
Main Authors: Mariana Igoillo-Esteve, Dante Maugeri, Ana L. Stern, Paula Beluardi, Juan J. Cazzulo
Format: Artigo
Sprog:Inglês
Udgivet: Academia Brasileira de Ciências 2007
Fag:
Multidisciplinaria (Ciencias Naturales y Exactas)
Chagas disease
oxidative stress
NADPH generation
Trypanosoma cruzi
pentose phosphate pathway
Online adgang:https://www.redalyc.org/articulo.oa?id=32779407
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