The pentose phosphate pathway in Trypanosoma cruzi: a potential target for the chemotherapy of Chagas disease

Trypanosoma cruzi is highly sensitive to oxidative stress caused by reactive oxygen species. Trypanothione, theparasite’s major protection against oxidative stress, is kept reduced by trypanothione reductase, using NADPH; themajor source of the reduced coenzyme seems to be the pentose phosphate path...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Anais da Academia Brasileira de Ciências
Hlavní autoři: Mariana Igoillo-Esteve, Dante Maugeri, Ana L. Stern, Paula Beluardi, Juan J. Cazzulo
Médium: Artigo
Jazyk:Inglês
Vydáno: Academia Brasileira de Ciências 2007
Témata:
Multidisciplinaria (Ciencias Naturales y Exactas)
Chagas disease
oxidative stress
NADPH generation
Trypanosoma cruzi
pentose phosphate pathway
On-line přístup:https://www.redalyc.org/articulo.oa?id=32779407
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky