Isolation and Characterization of Point Mutations in Mismatch Repair Genes That Destabilize Microsatellites in Yeast

The stability of simple repetitive DNA sequences (microsatellites) is a sensitive indicator of the ability of a cell to repair DNA mismatches. In a genetic screen for yeast mutants with elevated microsatellite instability, we identified strains containing point mutations in the yeast mismatch repair...

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Bibliographic Details
Main Authors: Sia, Elaine Ayres, Dominska, Margaret, Stefanovic, Lela, Petes, Thomas D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
DNA Dynamics and Chromosome Structure
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC99980/
https://ncbi.nlm.nih.gov/pubmed/11689704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.23.8157-8167.2001
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