Signaling through a Novel Domain of gp130 Mediates Cell Proliferation and Activation of Hck and Erk Kinases

Interleukin-6 (IL-6) induces the activation of the Src family kinase Hck, which is associated with the IL-6 receptor β-chain, gp130. Here we describe the identification of an “acidic” domain comprising amino acids 771 to 811 of gp130 as a binding region for Hck, which mediates proliferative signalin...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Schaeffer, Michael, Schneiderbauer, Michaela, Weidler, Sascha, Tavares, Rosário, Warmuth, Markus, de Vos, Gabriele, Hallek, Michael
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2001
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99973/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11689697/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.23.8068-8081.2001
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