Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells

Previous studies have demonstrated hematopoietic stem cell amplification in vitro after the activation of three cell-surface receptors: flt3/flk2, c-kit, and gp130. We now show flt3-ligand and Steel factor alone will stimulate >85% of c-kit(+)Sca-1(+)lin(−) adult mouse bone marrow cells to prolifera...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Audet, Julie, Miller, Cindy L., Rose-John, Stefan, Piret, James M., Eaves, Connie J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC29330/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11172024/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.98.4.1757
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