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Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells

Previous studies have demonstrated hematopoietic stem cell amplification in vitro after the activation of three cell-surface receptors: flt3/flk2, c-kit, and gp130. We now show flt3-ligand and Steel factor alone will stimulate >85% of c-kit(+)Sca-1(+)lin(−) adult mouse bone marrow cells to prolif...

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Autors principals: Audet, Julie, Miller, Cindy L., Rose-John, Stefan, Piret, James M., Eaves, Connie J.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC29330/
https://ncbi.nlm.nih.gov/pubmed/11172024
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