Construction and Analysis of Mouse Strains Lacking the Ubiquitin Ligase UBR1 (E3α) of the N-End Rule Pathway

The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. In the yeast Saccharomyces cerevisiae, the UBR1-encoded ubiquitin ligase (E3) of the N-end rule pathway mediates the targeting of substrate proteins in part through binding to their destabilizing N-t...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Kwon, Yong Tae, Xia, Zanxian, Davydov, Ilia V., Lecker, Stewart H., Varshavsky, Alexander
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2001
Assuntos:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99968/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11689692/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.23.8007-8021.2001
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