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Construction and Analysis of Mouse Strains Lacking the Ubiquitin Ligase UBR1 (E3α) of the N-End Rule Pathway

The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. In the yeast Saccharomyces cerevisiae, the UBR1-encoded ubiquitin ligase (E3) of the N-end rule pathway mediates the targeting of substrate proteins in part through binding to their destabilizing N-t...

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Udgivet i:Mol Cell Biol
Principais autores: Kwon, Yong Tae, Xia, Zanxian, Davydov, Ilia V., Lecker, Stewart H., Varshavsky, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2001
Fag:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99968/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11689692/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.23.8007-8021.2001
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