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N-Terminal Domains of the Human Telomerase Catalytic Subunit Required for Enzyme Activity in Vivo

Most tumor cells depend upon activation of the ribonucleoprotein enzyme telomerase for telomere maintenance and continual proliferation. The catalytic activity of this enzyme can be reconstituted in vitro with the RNA (hTR) and catalytic (hTERT) subunits. However, catalytic activity alone is insuffi...

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Autori principali: Armbruster, Blaine N., Banik, Soma S. R., Guo, Chuanhai, Smith, Allyson C., Counter, Christopher M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC99947/
https://ncbi.nlm.nih.gov/pubmed/11604512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.22.7775-7786.2001
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