Mitochondrial Import Driving Forces: Enhanced Trapping by Matrix Hsp70 Stimulates Translocation and Reduces the Membrane Potential Dependence of Loosely Folded Preproteins

The mitochondrial heat shock protein Hsp70 (mtHsp70) is essential for driving translocation of preproteins into the matrix. Two models, trapping and pulling by mtHsp70, are discussed, but positive evidence for either model has not been found so far. We have analyzed a mutant mtHsp70, Ssc1-2, that sh...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Principais autores:	Geissler, Andreas, Rassow, Joachim, Pfanner, Nikolaus, Voos, Wolfgang
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis 2001
Assuntos:	Cell and Organelle Structure and Assembly
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99885/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11564892/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.20.7097-7104.2001
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