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Mitochondrial Import Driving Forces: Enhanced Trapping by Matrix Hsp70 Stimulates Translocation and Reduces the Membrane Potential Dependence of Loosely Folded Preproteins

The mitochondrial heat shock protein Hsp70 (mtHsp70) is essential for driving translocation of preproteins into the matrix. Two models, trapping and pulling by mtHsp70, are discussed, but positive evidence for either model has not been found so far. We have analyzed a mutant mtHsp70, Ssc1-2, that sh...

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Bibliografiske detaljer
Udgivet i:	Mol Cell Biol
Principais autores:	Geissler, Andreas, Rassow, Joachim, Pfanner, Nikolaus, Voos, Wolfgang
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 2001
Fag:	Cell and Organelle Structure and Assembly
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99885/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11564892/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.20.7097-7104.2001
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Mitochondrial Import Driving Forces: Enhanced Trapping by Matrix Hsp70 Stimulates Translocation and Reduces the Membrane Potential Dependence of Loosely Folded Preproteins

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