Mitochondrial Import Driving Forces: Enhanced Trapping by Matrix Hsp70 Stimulates Translocation and Reduces the Membrane Potential Dependence of Loosely Folded Preproteins

The mitochondrial heat shock protein Hsp70 (mtHsp70) is essential for driving translocation of preproteins into the matrix. Two models, trapping and pulling by mtHsp70, are discussed, but positive evidence for either model has not been found so far. We have analyzed a mutant mtHsp70, Ssc1-2, that sh...

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Detalles Bibliográficos
Autores principales: Geissler, Andreas, Rassow, Joachim, Pfanner, Nikolaus, Voos, Wolfgang
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2001
Materias:
Cell and Organelle Structure and Assembly
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC99885/
https://ncbi.nlm.nih.gov/pubmed/11564892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.20.7097-7104.2001
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