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Allosteric inhibitors of telomerase: oligonucleotide N3′→P5′ phosphoramidates

Telomerase is a ribonucleoprotein responsible for maintaining telomeres in nearly all eukaryotic cells. The enzyme is able to utilize a short segment of its RNA subunit as the template for the reverse transcription of d(TTAGGG) repeats onto the ends of human chromosomes. Transfection with telomerase...

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Bibliographic Details
Main Authors: Pruzan, Ronald, Pongracz, Krisztina, Gietzen, Kimberly, Wallweber, Gerald, Gryaznov, Sergei
Format: Artigo
Language:Inglês
Published: Oxford University Press 2002
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC99832/
https://ncbi.nlm.nih.gov/pubmed/11788719
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