Combined, Functional Genomic-Biochemical Approach to Intermediary Metabolism: Interaction of Acivicin, a Glutamine Amidotransferase Inhibitor, with Escherichia coli K-12

Acivicin, a modified amino acid natural product, is a glutamine analog. Thus, it might interfere with metabolism by hindering glutamine transport, formation, or usage in processes such as transamidation and translation. This molecule prevented the growth of Escherichia coli in minimal medium unless...

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Detalhes bibliográficos
Main Authors: Smulski, Dana R., Huang, Lixuan L., McCluskey, Michael P., Reeve, Mary Jane Gladnick, Vollmer, Amy C., Van Dyk, Tina K., LaRossa, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Genetics and Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC99633/
https://ncbi.nlm.nih.gov/pubmed/11344143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.183.11.3353-3364.2001
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