Combined, Functional Genomic-Biochemical Approach to Intermediary Metabolism: Interaction of Acivicin, a Glutamine Amidotransferase Inhibitor, with Escherichia coli K-12

Acivicin, a modified amino acid natural product, is a glutamine analog. Thus, it might interfere with metabolism by hindering glutamine transport, formation, or usage in processes such as transamidation and translation. This molecule prevented the growth of Escherichia coli in minimal medium unless...

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Bibliographische Detailangaben
Hauptverfasser: Smulski, Dana R., Huang, Lixuan L., McCluskey, Michael P., Reeve, Mary Jane Gladnick, Vollmer, Amy C., Van Dyk, Tina K., LaRossa, Robert A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Genetics and Molecular Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC99633/
https://ncbi.nlm.nih.gov/pubmed/11344143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.183.11.3353-3364.2001
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