Analysis of SM22α-Deficient Mice Reveals Unanticipated Insights into Smooth Muscle Cell Differentiation and Function

SM22α is a 22-kDa smooth muscle cell (SMC) lineage-restricted protein that physically associates with cytoskeletal actin filament bundles in contractile SMCs. To examine the function of SM22α, gene targeting was used to generate SM22α-deficient (SM22(−/−LacZ)) mice. The gene targeting strategy emplo...

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Detalhes bibliográficos
Main Authors: Zhang, Janet C. L., Kim, Steven, Helmke, Brian P., Yu, William W., Du, Kevin L., Lu, Min Min, Strobeck, Mark, Yu, Qian-Chun, Parmacek, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC99586/
https://ncbi.nlm.nih.gov/pubmed/11158319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.2001.21.4.1336-1344.2001
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