Multiple Overlapping Epitopes in the Repetitive Unit of the Shed Acute-Phase Antigen from Trypanosoma cruzi Enhance Its Immunogenic Properties

The repetitive shed acute-phase antigen (SAPA) from Trypanosoma cruzi was thoroughly mapped by SPOT peptides and phage display strategies, showing that a single SAPA repeat is composed of multiple overlapping B-cell epitopes. We propose that this intricate antigenic structure constitutes an alternat...

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Detalhes bibliográficos
Main Authors: Alvarez, Paula, Leguizamón, M. Susana, Buscaglia, Carlos A., Pitcovsky, Tamara A., Campetella, Oscar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC98897/
https://ncbi.nlm.nih.gov/pubmed/11705983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.12.7946-7949.2001
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