Modification of Lipid A Biosynthesis in Neisseria meningitidis lpxL Mutants: Influence on Lipopolysaccharide Structure, Toxicity, and Adjuvant Activity

Two genes homologous to lpxL and lpxM from Escherichia coli and other gram-negative bacteria, which are involved in lipid A acyloxyacylation, were identified in Neisseria meningitidis strain H44/76 and insertionally inactivated. Analysis by tandem mass spectrometry showed that one of the resulting m...

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Publié dans:	Infect Immun
Auteurs principaux:	van der Ley, Peter, Steeghs, Liana, Hamstra, Hendrik Jan, ten Hove, Jan, Zomer, Bert, van Alphen, Loek
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2001
Sujets:	Molecular Pathogenesis
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC98725/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11553534/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.10.5981-5990.2001
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