Modification of Lipid A Biosynthesis in Neisseria meningitidis lpxL Mutants: Influence on Lipopolysaccharide Structure, Toxicity, and Adjuvant Activity

Two genes homologous to lpxL and lpxM from Escherichia coli and other gram-negative bacteria, which are involved in lipid A acyloxyacylation, were identified in Neisseria meningitidis strain H44/76 and insertionally inactivated. Analysis by tandem mass spectrometry showed that one of the resulting m...

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Главные авторы: van der Ley, Peter, Steeghs, Liana, Hamstra, Hendrik Jan, ten Hove, Jan, Zomer, Bert, van Alphen, Loek
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2001
Предметы:
Molecular Pathogenesis
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC98725/
https://ncbi.nlm.nih.gov/pubmed/11553534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.10.5981-5990.2001
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